Endoluminal delivery of anesthesia
Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector. The methods of selectively applying anesthetic to a target structure generally include the steps of inserting an injection catheter into a body vessel, positioning the injection catheter within the body vessel near the target structure, anchoring the injection catheter before extending a directional injector from the injection catheter, and applying anesthetic from the injection catheter to the target structure.
1. A method of applying anesthetic to a target structure from within a body vessel without substantially applying anesthetic to non-target structures, the method comprising:
inserting an injection catheter into a body vessel, wherein the injection catheter comprises a directional injector configured to apply anesthetic selectively to the target structure, wherein the target structure comprises a region surrounding the sinus nerve;
positioning the injection catheter within the body vessel near the target structure;
anchoring the injection catheter by deploying a stiff member to which the injection catheter couples;
extending the directional injector to deliver anesthetic to the target structure; and
applying anesthetic from the injection catheter to the target structure.
2. The method of claim 1 , further comprising the step of visualizing the injection catheter.
3. The method of claim 2 , further comprising visualizing the injection catheter by fluoroscopic visualization.
4. The method of claim 1 , further comprising the step of visualizing the application of anesthetic to the target structure.
5. The method of claim 4 , wherein the step of visualizing the application of anesthetic to the target structure comprises releasing radiopaque substance with the anesthetic.
6. The method of claim 1 , wherein the step of extending the directional injector comprises monitoring the orientation of the directional injector so that the directional injector is positioned near the target structure.
7. The method of claim 1 , wherein the step of anchoring the injection catheter comprises inflating a balloon connected to the injection catheter to secure the injection catheter within the body vessel.
8. The method of claim 1 , wherein the target structure comprises the sinus nerve.