Silane bonded medical devices and method of making same
View Patent ↗A method for bonding a graft material to a support element employing a silane coupling agent, and a medical device obtainable by the method. A medical device including a graft material bound to a support element by a plurality of silane linkages is also described.
1. A method of bonding a sheet of graft material to a metallic support element, the method comprising:
placing the sheet of graft material in contact with the metallic support element in the presence of a silane coupling agent; and
heating the graft material, metallic support element, and silane coupling agent to an effective temperature less than a melting point of the graft material to bond the graft material to the metallic support element.
2. The method of claim 1 , wherein the graft material comprises a polymer material selected from the group consisting of polyethylene, ultra high molecular weight polyethylene, polypropylene, polyethylene terephthalate, expanded polytetrafluoroethylene, polyurethane, and polyetherurethane.
3. The method of claim 1 , wherein the metallic support element comprises a metallic material selected from the group consisting of a nickel-titanium alloy, stainless steel, and a cobalt-chromium alloy, and the graft material is bonded to the metallic material.
4. The method of claim 3 , wherein the metallic support element comprises a nickel-titanium alloy.
5. The method of claim 1 , wherein the silane coupling agent is a compound of formula Ia:
wherein:
X 1 , X 2 , and X 3 are independently selected from the group consisting of C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, Cl, Br, and I; and
L is a bond or a substituted or unsubstituted C 1 -C 6 alkanediyl group.
6. The method of claim 5 , wherein the silane coupling agent is vinyltrimethoxysilane.
7. The method of claim 5 , wherein said heating the graft material, metallic support element, and silane coupling agent is conducted in the presence of a radical initiator.
8. The method of claim 7 , wherein the radical initiator is a peroxide selected from the group consisting of dibenzyl peroxide and dicumyl peroxide.
9. The method of claim 5 , wherein said heating the graft material, metallic support element, and silane coupling agent is performed under high humidity conditions.
10. The method of claim 1 , wherein the silane coupling agent is a compound of formula Ib:
wherein:
X 1 , X 2 , and X 3 are independently selected from a group consisting of C 1 -C 4 alkoxy, C 1 -C 4 acyloxy, Cl, Br, and I;
Y is selected from the group consisting of SO 2 , C(O), OC(O), and a bond; and
L is selected from a group consisting of a substituted or unsubstituted alkanediyl group, (CH 2 ) n (C 6 H 4 )(CH 2 ) p , wherein n=an integer between 0 and 4, and p=an integer between 2 and 4.
11. The method of claim 10 , wherein Y is selected from the group consisting of SO 2 , C(O), and OC(O).
12. The method of claim 11 , wherein Y is SO 2 .
13. The method of claim 12 , wherein the silane coupling agent is 6-azidosulfonylhexyltriethoxysilane.
14. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises:
applying the silane coupling agent to the graft material to form a treated graft material; and
placing the treated graft material in contact with the metallic support element.
15. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises:
applying the silane coupling agent to the metallic support element to form a treated support element; and
placing the graft material in contact with the treated support element.
16. The method of claim 1 , wherein said placing the graft material in contact with the metallic support element in the presence of a silane coupling agent comprises;
placing the graft material in contact with the metallic support element; and
applying the silane coupling agent to the graft material and the metallic support element.