Provided is a compound represented by the formula (1): wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, R 3 is a hydrogen atom, an alkyl group having a carbon number of 1-4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group, or a pharmaceutically acceptable salt thereof, which has, unlike known PGI 2 analogs, a selective EP4 agonist action, and a medicament containing the compound, which is useful for the prophylaxis and/or treatment of immune diseases, diseases of the digestive tract, cardiovascular diseases, cardiac diseases, respiratory diseases, neurological diseases, ophthalmic diseases, renal diseases, hepatic diseases, bone diseases, skin diseases and the like.
1. A method of treating osteoporosis in a subject, comprising administrating an effective amount of a compound of formula (1):
wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 to 3, and R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 to 4, an alkoxyalkyl group, an aryl group, a halogen atom, or a haloalkyl group, or a pharmaceutically acceptable salt thereof, as an active ingredient to a subject with osteoporosis, thereby treating osteoporosis in the subject.
2. A method of treating a bone fracture in a subject, comprising administrating an effective amount of a compound of formula (1):
wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 to 3, and R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 to 4, an alkoxyalkyl group, an aryl group, a halogen atom, or a haloalkyl group, or a pharmaceutically acceptable salt thereof, as an active ingredient to a subject with a bone fracture, thereby treating the bone fracture in the subject.
3. A method of treating neuronal cell death in a subject, comprising administrating an effective amount of a compound of formula (1):
wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 to 3, and R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 to 4, an alkoxyalkyl group, an aryl group, a halogen atom, or a haloalkyl group, or a pharmaceutically acceptable salt thereof, as an active ingredient to a subject with neuronal cell death, thereby treating neuronal cell death in the subject.
4. A method of treating amyotrophic lateral sclerosis in a subject, comprising administrating an effective amount of a compound of formula (1):
wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 to 3, and R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 to 4, an alkoxyalkyl group, an aryl group, a halogen atom, or a haloalkyl group, or a pharmaceutically acceptable salt thereof, as an active ingredient to a subject with amyotrophic lateral sclerosis, thereby treating amyotrophic lateral sclerosis in the subject.
5. A method of treating multiple sclerosis in a subject, comprising administrating an effective amount of a compound of formula (1):
wherein R 1 and R 2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1 to 3, and R 3 is a hydrogen atom, an alkyl group having a carbon number of 1 to 4 an alkoxyalkyl group, an aryl group, a halogen atom, or a haloalkyl group, or a pharmaceutically acceptable salt thereof, as an active ingredient to a subject with multiple sclerosis, thereby treating multiple sclerosis in the subject.