IP Library › Patent Application 13676626
Patent Application
App. No. 13/676,626

AMYLOID BETA PEPTIDES, ASSEMBLIES THEREOF, AND RELATED METHODS

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Quick Facts
Patent No.
US None
App. No.
13/676,626
Abstract

The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid β peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid β peptide subunits.

Claims (3)

1 . An amyloid beta peptide having the amino acid sequence Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-(D)Pro-Gly-Val-Val-Ile-Ala (SEQ ID NO:41).

2 . A composition comprising the amyloid beta peptide of claim 1 in admixture with an adjuvant.

3 . An isolated antibody that specifically binds to the amyloid beta peptide of claim 1 .

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 6, 2012
From: NORTHWESTERN UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029422/0549 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 14, 2012
From: KRAFFT, GRANT A.
To: ACUMEN PHARMACEUTICALS, INC.
Reel/Frame 029296/0613 →