Composition for repelling and deterring vermin
View Patent ↗The present invention is directed to a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I) as described herein. Further, the present invention is directed to corresponding vermin-deterring compositions which contain these substances as the active ingredient, compounds of the formula (I) for the preparation of vermin-deterring compositions, and the use of compounds of formula (I) in the defense against vermin.
1. ; A process for deterring vermin from warm-blooded animals, whereby a compound of formula I
or an acid addition salt thereof, wherein
R1 is hydrogen or halogen;
m is 1, 2 or 3;
R2 is hydrogen, halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 alkyl, halo-C 1 -C 20 -alkyl, C 2 -C 20 -alkenylalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl;
R3 is
R4 is hydrogen, C 1 -C 20 -alkyl, benzyl, —C(O)—R8;
n is 0 or 1; and
R8 is C 1 -C 20 -alkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, benzyl; is applied topically, together with a spreading additive, to the skin, the pelt or the plumage of the warm-blooded animal.
2. A process according to claim 1 , wherein the compound of formula I is a compound of the formula Ib or one of its acid addition salts
wherein R1, R2, R4 and m have the meanings specified under formula I.
3. A process according to claim 2 , wherein m is 1 or 2, R2 is hydrogen, C 1 -C 3 -alkyl, or phenyl; and R4 is hydrogen or acetyl.
4. A process according to claim 1 , wherein the compound of formula I is a compound of the formula Ic or one of its acid addition salts
wherein R1, R2, R4 and m have the meanings specified under formula I.
5. A process according to claim 4 , wherein m is 1 or 2, R2 is hydrogen, C 1 -C 3 -alkyl, or phenyl; and R4 is hydrogen or acetyl.
6. A process according to claim 1 wherein the compound of formula I is applied in the form of a pour-on or spot-on formulation.
7. The process of claim 4 , wherein R1, R2 and R4 in compound Ic are each H.
8. A topically applied composition comprising a compound of formula I
or an acid addition salt thereof and a spreading additive,
wherein
R1 is hydrogen or halogen
m is 1, 2 or 3:
R2 is hydrogen, halogen, unsubstituted or substituted benzyl, —C(O)—R8, C 1 -C 20 -alkyl, halo-C 1 -C 20 -alkyl, C 2 -C 20 -alkenylalkyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkoxyalkyl, C 1 -C 20 -hydroxyalkyl, C 1 -C 20 -alkoxy, unsubstituted or substituted aryl;
R3 is
R4 is hydrogen, C 1 C 20 -alkyl, benzyl, —C(O)—R8;
n is 0 or 1; and
R8 is C 1 -C 20 -alkyl, C 1 C 20 -alkoxy, unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, or benzyl; wherein the composition is effective in repelling vermin from warm-blooded animals.
9. A process for the preparation of a composition for repelling vermin, wherein a compound of formula I according to claim 8 is mixed with a spreading additive.