Anti c-Met antibody and uses thereof
An anti c-Met antibody or antigen-binding fragment thereof comprising a heavy-chain variable region having heavy-chain complementarity determining region (CDR) amino acid sequences of SEQ ID NOs: 1, 2 and 3, and a light-chain variable region having light-chain CDR amino acid sequences of SEQ ID NOs: 4, 5, and 6; and a method of wound healing, tissue regeneration, or cell proliferation comprising administration of same; as well as related compositions and methods.
1. An isolated anti c-Met antibody or antigen-binding fragment thereof comprising a heavy-chain variable region having heavy-chain complementarity determining region (CDR) amino acid sequences of SEQ ID NOs: 1, 2 and 3, and a light-chain variable region having light-chain CDR amino acid sequences of SEQ ID NOs: 4, 5, and 6.
2. The anti c-Met antibody or antigen-binding fragment of claim 1 comprising a heavy-chain variable region having an amino acid sequence of SEQ ID No. 7, and a light-chain variable region having an amino acid sequence of SEQ ID No. 8.
3. The anti c-Met antibody or antigen-binding fragment thereof of claim 1 , wherein the c-Met is human c-Met, monkey c-Met, mouse c-Met, or rat c-Met.
4. The anti c-Met antibody or antigen-binding fragment thereof of claim 1 , wherein the anti c-Met antibody is a monoclonal antibody.
5. An antigen-binding fragment of an anti c-Met antibody according to claim 1 .
6. The antigen-binding fragment of claim 5 , wherein the antigen-binding fragment is selected from the group consisting of scFv, (scFv) 2 , Fab, Fab′, and F(ab′) 2 .
7. A polynucleotide comprising a nucleotide sequence encoding the antibody or antigen-binding fragment of claim 1 .
8. A polynucleotide comprising a nucleotide sequence encoding the antibody or antigen-binding fragment of claim 2 .
9. A recombinant vector comprising the polynucleotide of claim 7 .
10. A recombinant vector comprising the polynucleotide of claim 8 .
11. A host cell comprising the polynucleotide of claim 9 .
12. A host cell comprising the polynucleotide of claim 10 .
13. A pharmaceutical composition comprising the antibody or antibody fragment of claim 1 and a pharmaceutically acceptable carrier, diluent, or excipient.
14. A pharmaceutical composition comprising the antibody or antibody fragment of claim 2 and a pharmaceutically acceptable carrier, diluent, or excipient.
15. A method for wound healing or tissue regeneration that comprises administering to a subject an anti c-Met antibody or antigen-binding fragment of claim 1 .
16. The method of claim 15 , wherein the method comprises administering an antigen-binding antibody fragment selected from the group consisting of scFv, (scFv) 2 , Fab, Fab′, and F(ab′) 2 .
17. A method for wound healing or tissue regeneration that comprises administering to a subject an anti c-Met antibody or antigen binding fragment thereof of claim 2 .
18. The method of claim 17 , wherein the method comprises administering an antigen-binding antibody fragment is selected from the group consisting of scFv, (scFv) 2 , Fab, Fab′, and F(ab′) 2 .
19. A method for facilitating cell proliferation that comprises administering to a subject the anti c-Met antibody or antigen-binding fragment thereof of claim 1 .
20. The method of claim 19 , wherein the method comprises administering an antigen-binding antibody fragment selected from the group consisting of scFv, (scFv) 2 , Fab, Fab′, and F(ab′) 2 .
21. A method for facilitating cell proliferation that comprises administering to a subject the anti c-Met antibody or antigen-binding fragment thereof of claim 2 .
22. The method of claim 21 , wherein the method comprises administering an antigen-binding antibody fragment selected from the group consisting of scFv, (scFv) 2 , Fab, Fab′, and F(ab′) 2 .