Glucose management and dialysis method and apparatus

1. A process for treating a patient, the process comprising:

removing blood from the patient and passing the blood through a treatment device to treat the blood, where said treatment device is a dialyser to treat the blood by removing wastes from the blood;

measuring the glucose level of the blood;

directing the blood to a glucose scavenging unit when the measured glucose level is measured above a threshold level and removing glucose from the blood, and producing a reduced glucose level blood, or directing the blood to a glucose increasing unit when the measured glucose is below a threshold level and increasing the blood glucose level, where said glucose scavenging unit is positioned in a line between the dialyser and the patient; and

returning the resulting treated blood to said patient.

2. The process of claim 1 , wherein said method further comprises

passing said blood through said glucose scavenging unit before passing through said dialyser.

3. The process of claim 1 , wherein

said glucose scavenging unit includes a glucose scavenger selected from the group consisting of a glucose binding protein, a boronic acid and a boronic ester and mixtures thereof on a support and where the glucose scavenger has a predetermined glucose binding constant Kd.

4. The process of claim 3 , where said boronic acid is selected from the group consisting of phenyl boronic acid, naphthyl boronic acid and anthracenyl boronic acid.

5. The process of claim 3 , wherein

said support comprises a porous membrane.

6. The process of claim 3 , wherein

said scavenging unit comprises a length of flexible tubing having an inner surface with the glucose binding protein bonded thereto.

7. The process of claim 6 , wherein

said glucose binding protein, boronic acid or boronic ester is covalently bonded to the inner surface of said tubing.

8. The process of claim 1 , further comprising

introducing glucose or D50 into the blood in the glucose increasing unit to increase the blood glucose level to a predetermined range.

9. The process of claim 1 , further comprising

introducing glucagon to the blood in the glucose increasing unit to promote glucose production in the patient.

10. A dialysis process comprising:

removing blood from a patient to a dialyser to remove waste from the blood;

monitoring blood glucose levels in the blood and detecting glucose levels above a predetermined threshold and/or below a predetermined threshold;

directing the blood to one of a glucose scavenger when the blood glucose level of the blood is above said threshold level and removing the glucose from said blood, or to a glucose increasing unit for increasing a blood glucose level when the blood glucose level is below said predetermined threshold level and increasing the blood glucose level, where said glucose scavenging unit is positioned in a line between the dialyser and the patient; and

thereafter returning said blood to said patient.

11. The process of claim 10 , further comprising

passing the blood through the glucose scavenger before passing through the dialyser.

12. The process of claim 10 , further comprising

passing the blood through the glucose scavenger after passing through the dialyser.

13. The process of claim 10 , wherein

said glucose scavenger comprises a cartridge connected to the dialyzer and where said glucose scavenger is selected from the group consisting of glucose binding proteins, boronic acids, boronic esters and mixtures thereof fixed to a support.

14. The process of claim 13 , wherein

said glucose scavenger is a glucose binding protein having a predetermined glucose binding constant Kd.

15. The process of claim 10 , wherein

said glucose scavenger comprises a conduit having an inner wall with the glucose binding protein, boronic acid or boronic ester covalently bonded thereto and said process further comprises passing said blood through said conduit before returning said blood to said patient.

16. The process of claim 10 , further comprising

introducing glucose or D50 to the blood in the glucose increasing unit when the measured blood glucose level is below the predetermined threshold level.

17. The process of claim 10 , further comprising

introducing glucagon into the blood in the glucose increasing unit when the measured blood glucose level is below the predetermined threshold level to promote glucose production in the patient.

18. A dialysis apparatus comprising:

a first supply line for removing blood from a patient;

a dialyser unit coupled to said first supply line for receiving the blood from the patient, and for treating the blood by removing waste from said blood;

a glucose monitoring unit receiving the blood for measuring a glucose level in the blood, detecting a blood glucose level in the blood above a threshold level and detecting a blood glucose level in the blood below a threshold level;

a glucose scavenging unit having a glucose scavenger selected from the group consisting of glucose binding proteins, boronic acids, boronic esters and mixtures thereof, said glucose scavenger adapted for receiving the blood and removing a predetermined amount of glucose from the blood when the glucose level is above said threshold level; and

a second supply line for returning treated blood from said dialyser to the patient.

19. The dialysis apparatus of claim 18 , wherein

said glucose scavenging unit comprises a cartridge and is positioned upstream of said dialyser unit.

20. The dialysis apparatus of claim 18 , wherein

said glucose scavenging unit comprises a cartridge and is positioned downstream of said dialyser unit.

21. The dialysis apparatus of claim 18 , further comprising

a control unit for diverting blood to said glucose scavenging unit when the detected glucose level in the blood is above the threshold level.

22. The dialysis apparatus of claim 18 , wherein

said first supply line or second supply line comprises a tube having an inner surface with the glucose scavenger covalently bonded thereto for scavenging a predetermined amount of glucose from said blood.

23. The dialysis apparatus of claim 18 , further comprising

a glucose increasing unit positioned downstream of said dialyser for increasing blood glucose levels in said blood, and where said control unit directs said blood from said dialyser to said device when the measured blood glucose level is below a threshold level.

24. The dialysis apparatus of claim 23 , wherein

said glucose increasing unit introduces glucose or D50 into the blood to increase the blood glucose level to a predetermined level.

25. The dialysis apparatus of claim 23 , wherein

said glucose increasing unit introduces glucagon into the blood to promote glucose production in the patient.

26. The dialysis apparatus of claim 23 , wherein

said glucose increasing unit includes a glucose binding protein, a boronic acid or boronic ester charged with glucose for releasing glucose to the blood.