Substituted tetracycline compounds
View Patent ↗The present invention pertains to tetracycline compounds of formula (VIIa): R 5* , R 5*′ , R 7r* , and R 9m* are defined herein. These tetracycline compounds can be used to treat tetracycline compound-responsive states, such as multiple sclerosis and rheumatoid arthritis.
1. A tetracycline compound of formula (VIIa):
wherein
X is CR 6* CR 6* ;
R 5* is hydrogen;
R 5*′ is hydrogen hydroxyl;
R 6*′ is hydrogen or alkyl;
R 6* is hydrogen;
R 7r* alkylamino; and
R 9m* is oxazolyl or isoxazolyl, or a pharmaceutically acceptable salt thereof.
2. The tetracycline compound of claim 1 , wherein oxazolyl is substituted with methyl or isopropyl.
3. The tetracycline compound of claim 1 , wherein R 7r* is dialkylamino.
4. The tetracycline compound of claim 1 , wherein R 7r* is dimethylamino.
5. The tetracycline compound of claim 1 , wherein each of R 5* , R 5*′ , R 6* , and R 6*′ is hydrogen.
6. The tetracycline compound of claim 5 , wherein R 7r* is dialkylamino.
7. The tetracycline compound of claim 6 , wherein R 7r* is dimethylamino.
8. The tetracycline compound of claim 1 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
9. A pharmaceutical composition comprising a tetracycline compound of claim 1 and a pharmaceutical acceptable carrier.
10. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
11. A method for treating multiple sclerosis in a subject, comprising administering to said subject an effective amount of a tetracycline compound of any one of claims 1 , 2 , 3 to 7 , 8 or 10 , such that said subject is treated.