Anticoagulant reversal agents
View Patent ↗Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.
1. A compound represented by formula II:
or a pharmaceutically acceptable salt thereof, wherein:
L and L′ are each a substituted or unsubstituted C 1 to C 10 alkylene chain;
M and M′ are each a substituted C 1 to C 10 alkylene chain; and
Y and Y′ are each
2. The compound of claim 1 , wherein L and/or L′ is a substituted or unsubstituted alkylene chain that is C 1 to C 6 .
3. The compound of claim 1 , wherein the compound is represented by formula III:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 3 , wherein the compound is represented by formula IV:
or a pharmaceutically acceptable salt thereof,
wherein n is 3 to 5, m is 3 to 6 and G is selected from —NH 2 and OH.
5. The compound of claim 4 , wherein G is amino.
6. A compound of formula V
or a pharmaceutically acceptable salt thereof.
7. A compound of formula VI
or a pharmaceutically acceptable salt thereof.
8. A compound of formula VII
or a pharmaceutically acceptable salt thereof.
9. A compound of formula VIII
or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition comprising the compound of any one of claims 2 - 5 and 6 - 9 and a pharmaceutically acceptable carrier.
11. The pharmaceutical composition of claim 10 , wherein the composition is adapted for enteral administration.
12. The pharmaceutical composition of claim 11 , wherein the composition is adapted for oral administration.
13. The pharmaceutical composition of claim 10 , wherein the composition is adapted for parenteral administration.
14. The pharmaceutical composition of claim 13 , wherein the composition is adapted for intravenous or subcutaneous administration.
15. The pharmaceutical composition of claim 12 , wherein the composition is a daily dosage that comprises the compound in an amount of about 0.01 mg/kg to about 100 mg/kg of body weight of a patient.
16. The pharmaceutical composition of claim 15 , wherein the daily dosage composition comprises the compound in an amount of about 0.01 mg/kg to about 25 mg/kg of body weight of the patient.
17. The pharmaceutical composition of claim 12 , wherein the composition is in the form of a capsule or tablet.
18. The pharmaceutical composition of claim 12 , wherein the composition is an aqueous solution.