Mucosal formulation
View Patent ↗Provided, among other things, is a method of treating or ameliorating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a rinse comprising: an effective amount of appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea ; an antimicrobially effective amount of a quaternary ammonium surfactant; and optionally a polymer or mixture of polymers effective to coat said tissue and entrap said extract(s).
1. A method of treating or ameliorating an indication of anal or vaginal mucosal tissue comprising periodically applying to anal or vaginal mucosa at or adjacent to disease affected tissue a formulation comprising
an antiinflammatory effective amount of herbal extracts including Sambucus nigra, Centella asiatica and Echinacea purpurea defining a weight amount of plant extract solids in the formulation, wherein Sambucus nigra extract is more than 50% to 90% by weight of the plant extract solids and Centella asiatica is 1% to less than 50% by weight of the plant extract solids,
a plasticizer in an amount from 10 to 45% by weight of the formulation, and
an antimicrobially effective amount of a surfactant that is a 1-alkylpyridinium salt, where alkyl is C8-C36, the surfactant present in an amount from 0.01 to 2% of the formulation by weight.
2. The method of claim 1 , wherein the formulation comprises film-forming polymer(s).
3. The method of claim 2 , wherein the film-forming polymer(s) provide a mucoadhesive film.
4. The method of claim 1 , wherein the 1-alkylpyridinium salt is a cetylpyridinium salt.
5. The method of claim 4 , wherein Sambucus nigra extract comprises 60 to 90% by weight of plant extract solids in the formulation.
6. The method of claim 5 , wherein Centella asiatica extract comprises 1to 20% by weight of plant extract solids in the formulation.
7. The method of claim 6 , wherein Echinacea purpurea extract comprises 5 to 40% by weight of plant extract solids in the formulation.
8. The method of claim 1 , wherein the surfactant is present in an amount from 0.01 to 1% of the formulation by weight.
9. The method of claim 1 , wherein the formulation is a mucoadhesive solid.
10. The method of claim 9 , wherein Sambucus nigra extract comprises 60 to 90% by weight of plant extract solids in the formulation.
11. The method of claim 10 , wherein Centella asiatica extract comprises 1to 20% by weight of plant extract solids in the formulation.
12. The method of claim 11 , wherein Echinacea purpurea extract comprises 5 to 40% by weight of plant extract solids in the formulation.
13. The method of claim 1 , wherein Centella asiatica extract comprises 5to 40% by weight of plant extract solids in the formulation.
14. The method of claim 1 , wherein Echinacea purpurea extract comprises 1 to 20% by weight of plant extract solids in the formulation.
15. The method of claim 1 , comprising periodically applying the formulation to vaginal mucosa at or adjacent to disease affected tissue.
16. The method of claim 1 , wherein the formulation is a film, patch or mucoadhesive solid.
17. The method of claim 16 , comprising periodically applying the formulation to vaginal mucosa at or adjacent to disease affected tissue.
18. The method of claim 1 , wherein Sambucus nigra extract comprises 60to 99% by weight of plant extract solids in the formulation.
19. The method of claim 18 , wherein Centella asiatica extract comprises 1to 20% by weight of plant extract solids in the formulation.
20. The method of claim 19 , wherein Echinacea purpurea extract comprises 5 to 40% by weight of plant extract solids in the formulation.