Compositions and methods for treating neoplasia, inflammatory disease and other disorders
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
1. A compound represented by a structural formula selected from the group consisting of:
or a pharmaceutically acceptable salt of any of the foregoing.
2. A compound of claim 1 , represented by the structural formula
or a pharmaceutically acceptable salt thereof.
3. A compound of claim 1 , represented by the structural formula
or a pharmaceutically acceptable salt thereof.
4. A compound of claim 1 , represented by the structural formula
or a pharmaceutically acceptable salt thereof.
5. A compound of claim 1 , represented by the structural formula
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.