IP Library › Granted Patent US 8,962,569
Granted Patent B2
US 8,962,569 · App. 13/699,288 · Granted Feb 24, 2015

Compositions comprising spp24 peptide fragments

Inventors: Samuel S. Murray (Saugus, CA); Elsa J. Murray (Saugus, CA); Jeffrey C. Wang (Sherman Oaks, CA)
Assignees: The Regeants of the University of California; The United States of America as Represented by the Department of Veterans Affairs
A61K38/1709
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Quick Facts
Patent No.
US 8,962,569
App. No.
13/699,288
Granted
Feb 24, 2015
Kind
B2
Abstract

Provided herein is tumor suppression composition and methods of making and using the same.

Claims (9)

1. A composition, comprising a peptide fragment of secreted phosphoprotein 24 kD (spp24) (SEQ ID NO:1) that specifically binds BMP-2,

wherein said peptide fragment consists of amino acids 80-129 of spp24 or amino acids 110-128 of spp24.

2. The composition of claim 1 , in a local delivery formulation.

3. The composition of claim 1 , in a systemic delivery formulation.

4. The composition of claim 2 , wherein the local delivery formulation comprises a patch.

5. The composition of claim 1 , further comprising a pharmaceutically acceptable carrier.

6. The composition of claim 2 , wherein the local delivery formulation is suitable for injection.

7. The composition of claim 2 , wherein the local delivery formulation comprises a sustained release formulation.

8. The composition of claim 1 , wherein said peptide fragment is present in an amount effective to achieve a serum concentration of 0.01 nM to 1,000,000 nM.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 11, 2013
From: WANG, JEFFREY C.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 030200/0068 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 11, 2013
From: MURRAY, SAMUEL S.; MURRAY, ELSA J.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
Reel/Frame 030200/0106 →
Continuity (2)
Provisional Application 61348205 · May 25, 2010
Related Publication 20130143811A1 · Jun 6, 2013