IP Library Granted Patent US 8,598,087
Granted Patent B2
US 8,598,087 · App. 13/700,222 · Granted Dec 3, 2013

Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide

Inventor: Martin James Currie (Newark, DE)
Assignee: E. I. du Pont de Nemours and Company
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Quick Facts
Patent No.
US 8,598,087
App. No.
13/700,222
Granted
Dec 3, 2013
Kind
B2
Abstract

Disclosed is a solid form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide (Compound 1). Also disclosed are compositions containing a solid form of Compound 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a solid form of Compound 1 or a composition containing a solid form of Compound 1.

Claims (17)

1. A crystalline polymorph of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide designated Form B characterized by a powder X-ray diffraction pattern having at least the 2θ reflection positions

17.433,

18.586,

20.207,

20.791,

21.41,

22.112,

23.182,

24.567 and

27.844.

2. A composition comprising the polymorph Form B of claim 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, said composition optionally further comprising at least one additional compound or agent, wherein said additional compound or agent is biologically active.

3. A composition for protecting an animal from an invertebrate parasitic pest comprising a parasiticidally effective amount of the polymorph Form B of claim 1 and at least one carrier.

4. The composition of claim 3 in a dosage form for oral administration.

5. A method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of the polymorph Form B of claim 1 .

6. The method of claim 5 wherein the environment is a plant.

7. The method of claim 5 wherein the environment is an animal.

Assignments (3)
NUNC PRO TUNC ASSIGNMENT Recorded Feb 21, 2024
From: E.I. DU PONT DE NEMOURS AND COMPANY
To: CORTEVA AGRISCIENCE LLC
Reel/Frame 066507/0548 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2013
From: CURRIE, MARTIN JAMES
To: E. I. DU PONT DE NEMOURS AND COMPANY
Reel/Frame 029800/0764 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2012
From: CURRIE, MARTIN JAMES
To: E. I. DU PONT DE NEMOURS AND COMPANY
Reel/Frame 029444/0755 →
Continuity (2)
Provisional Application 61348958 · May 27, 2010
Related Publication 20130137735A1 · May 30, 2013