Compositions comprising buprenorphine
View Patent ↗This disclosure relates to a buprenorphine sustained release delivery system for treatment of conditions ameliorated by buprenorphine compounds. The sustained release delivery system includes a flowable composition containing a suspension of buprenorphine, a metabolite, or a prodrug thereof.
1. An injectable pharmaceutical composition comprising:
(a) 10 wt % to 20 wt % buprenorphine free base having an average particle size of less than 20 μm; and
(b) an aqueous solution comprising polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, or a combination thereof; and a polyethylene glycol polymer;
wherein the buprenorphine free base is suspended in the aqueous solution, and wherein the composition does not comprise one or both of a polylactide and polyglycolide polymer.
2. The composition of claim 1 , wherein the buprenorphine free base has an average particle size of less than 10 μm.
3. The composition of claim 1 , wherein the aqueous solution comprises polyoxyethylene (20) sorbitan monolaurate and a polyethylene glycol polymer having a molecular weight between 1,000 and 10,000.
4. The composition of claim 1 , wherein the aqueous solution comprises polyoxyethylene (20) sorbitan monooleate and a polyethylene glycol polymer having a molecular weight between 1,000 and 10,000.
5. The composition of claim 1 , wherein the aqueous solution comprises polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, and a polyethylene glycol polymer having a molecular weight between 1,000 and 10,000.
6. The composition of claim 1 , wherein the polyethylene glycol polymer has a molecular weight between 1,000 and 10,000.
7. The composition of claim 1 , wherein the aqueous solution further comprising a pharmaceutically acceptable salt, a pharmaceutically acceptable sugar, a preservative, or a combination of two or more thereof.
8. An injectable pharmaceutical composition comprising
(a) about 5 wt % to about 20 wt % of buprenorphine free base having an average particle size of less than 50 μm; and
(b) an aqueous solution comprising (i) polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, a poloxamer, a phospholipid, or a combination thereof, and (ii) a polyethylene glycol polymer, a carboxymethylcellulose, a polyvinylpyrrolidone, a polyvinylalcohol, or a dextran;
wherein the buprenorphine free base is suspended in the aqueous solution, and wherein the composition does not comprise one or both of a polylactide and polyglycolide polymer.
9. The composition of claim 8 comprising about 10 wt % to about 20 wt % buprenorphine free base.
10. The composition of claim 8 , wherein the buprenorphine free base has an average particle size of less than 20 μm.
11. The composition of claim 8 , wherein the aqueous solution comprises (i) polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, or a combination thereof, and (ii) a polyethylene glycol polymer.
12. The composition of claim 8 , wherein the aqueous solution further comprises a pharmaceutically acceptable salt, a pharmaceutically acceptable sugar, a preservative, or a combination of two or more thereof.
13. A pharmaceutical composition comprising buprenorphine or a pharmaceutically acceptable salt thereof, having an average particle size of less than 200 μm, suspended in an aqueous solution comprising a nonionic surfactant and a water-soluble polymer.
14. The composition of claim 13 , wherein the buprenorphine or the pharmaceutically acceptable salt thereof is present in an amount of about 10 wt % to about 20 wt %.
15. The composition of claim 13 , wherein the buprenorphine or the pharmaceutically acceptable salt thereof has an average particle size of is less than 100 μm.
16. The composition of claim 13 , wherein the buprenorphine is present as the free base (unprotonated) form.
17. The composition of claim 13 , wherein the buprenorphine is present as a pharmaceutically acceptable salt.
18. The composition of claim 13 , wherein the aqueous solution further comprises a pharmaceutically acceptable salt, a pharmaceutically acceptable sugar, a preservative, or a combination of two or more thereof.
19. The composition of claim 13 , wherein the nonionic surfactant is polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, a poloxamer, a phospholipid, or a combination thereof.
20. The composition of claim 13 , wherein the water-soluble polymer is a polyethylene glycol polymer, a carboxymethylcellulose, a polyvinylpyrrolidone, a polyvinylalcohol, a dextran, or a combination of two or more thereof.