IP Library › Granted Patent US 9,242,014
Granted Patent B2
US 9,242,014 · App. 13/703,864 · Granted Jan 26, 2016

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof

Inventors: Thomas J. Kipps (San Diego, CA); Jianqiang Yu (San Diego, CA)
Assignee: The Regents of The University of California
A61K47/48646C07K14/7051C07K14/70521C07K16/30C07K16/40C07K16/46C07K16/468G01N33/57492C07K2317/622C07K2319/00C07K2319/33G01N2333/705
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Quick Facts
Patent No.
US 9,242,014
App. No.
13/703,864
Granted
Jan 26, 2016
Kind
B2
Abstract

Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.

Claims (1)

1. An isolated scFv antibody comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, wherein the scFv binds to ROR1.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 20, 2012
From: UNIVERSITY OF CALIFORNIA SAN DIEGO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029507/0624 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2012
From: KIPPS, THOMAS J.; YU, JIANQIANG
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 029457/0033 →
Continuity (1)
Related Publication 20130101607A1 · Apr 25, 2013