Pacemaker for unilateral vocal cord autoparalysis
View Patent ↗A stimulation system and method for treating a human subject having unilateral vocal cord paralysis includes a sensing electrode configured to detect voice activity of a vocalizing muscle of the subject and to generate a first signal, and a processor configured to receive the first signal from the sensing electrode and to generate at least one stimulation parameter based on the first signal. The system further includes a stimulating electrode configured to receive the stimulation parameter from the processor and to activate a glottis closing reflex of the subject in response to the stimulation parameter.
1. A method of treating a human subject having unilateral vocal cord autoparalysis, the method comprising:
providing a sensing electrode configured to detect voice activity of the subject and to generate a first signal;
generating at least one stimulation parameter, using a processor, in response to receiving the first signal, the stimulation parameter being based on the first signal; and
activating a glottic closure reflex in response to receiving the stimulation parameter.
2. A method according to claim 1 , wherein the activating includes electrical stimulation, mechanical stimulation, or a combination thereof.
3. A method according to claim 1 , wherein the sensing electrode is configured to detect electromyographic (EMG) activity of a vocalizing muscle.
4. A method according to claim 1 , wherein the sensing electrode is configured to detect movement related to voice production.
5. A method according to claim 1 , wherein the sensing electrode is a microphone that detects acoustic signals related to voice production.
6. A method according to claim 1 , wherein the sensing electrode is an impedance sensor that detects changes of impedances related to voice production.
7. A method according to claim 1 , wherein the sensing electrode is a pressure sensor that detects changes in pressure related to voice production.
8. A method according to claim 1 , wherein the activating includes providing a current pulse having a duration of about 0.01 msec to 20 msec and a magnitude in the range of about 0.05 mA to 20 mA.
9. A method according to claim 1 , wherein the stimulation parameter includes a stimulation frequency that is approximately reciprocal to a contraction time of a vocal cord adductor of the subject.
10. A method according to claim 1 , wherein the stimulation parameter includes a stimulation frequency that is above a reciprocal of a contraction time of a vocal cord abductor of the subject.
11. A method according to claim 1 , wherein the stimulation parameter includes a stimulation voltage that is above a threshold for activation of vocal cord abductor muscles of the subject.
12. A method according to claim 1 , wherein the stimulation parameter includes a stimulation voltage that is above a threshold for activation of vocal cord adductor muscles of the subject.
13. A method according to claim 1 , wherein the stimulation parameter includes a stimulation voltage that is above a threshold for activation of vocal cord adductor muscles of the subject and below a threshold for activation of vocal cord abductor muscles of the subject.
14. A method according to claim 1 , wherein the stimulation parameter includes a stimulation voltage that is above a threshold for activation of vocal cord abductor muscles of the subject and above a threshold for activation of vocal cord adductor muscles of the subject.
15. A method according to claim 1 , wherein the stimulation parameter includes a stimulation voltage so that a net force for activation of adductor muscles is higher than a net force for activation of abductor muscles of the subject.
16. A method according to claim 1 , further comprising:
determining when the voice activity has reached a predetermined level, wherein the sensing electrode responds by generating the first signal when the predetermined level is reached.
17. A stimulation system for a human subject having unilateral vocal cord autoparalysis, the system comprising:
a manual activator configured to generate a first signal;
a processor configured to receive the first signal and to generate at least one stimulation parameter, the stimulation parameter based on the first signal; and
a stimulating electrode configured to receive the stimulation parameter from the processor and to activate a glottic closure reflex of the subject based on the stimulation parameter.
18. A system according to claim 17 , wherein the manual activator is a switch operable by the subject.
19. A system according to claim 17 , wherein the processor is configured to receive the first signal by inductive coupling, capacitive coupling, electromagnetic transmission, light coupling, vibratory coupling, mechanical coupling, acoustical coupling or combinations thereof.
20. A pacemaker system for a human subject having unilateral vocal cord autoparalysis, the system comprising:
a sensing electrode configured to detect voice activity of the subject and to generate a first signal;
a processor in communication with the sensing electrode, the processor having program code for receiving the first signal and for generating at least one stimulation parameter based on the first signal in order to activate a glottic closure reflex of the subject; and
a stimulating electrode configured to receive the stimulation parameter and to activate the glottic closure reflex of the subject based on the stimulation parameter.
21. A system according to claim 20 , wherein the stimulating electrode is a nerve cuff electrode, a rod electrode or combinations thereof.
22. A system according to claim 20 , wherein the stimulation electrode is configured to provide a range of stimulation voltages.
23. A system according to claim 20 , wherein the processor is configured to detect when the first signal has reached a predetermined level and configured to generate the stimulation parameter when the predetermined level is reached.