Method for bowel preparation
The present invention provides methods for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic procedure. The methods can improve patient compliance, and thus, efficacy of the preparation. Specifically, the present methods make the gastrointestinal tract preparation composition palatable for the patient to consume. For example, for a patient preparing to undergo colonoscopy, the present methods make the bowel preparation solution taste significantly less salty.
1. A method for cleansing the gastrointestinal tract of a patient in need of an endoscopy, a gastrointestinal tract surgery or a barium enema, the method comprising the steps of:
(a) determining the pH of a gastrointestinal tract preparation composition which has a salty taste, and adjusting the pH to range from about 3 to about 6.4;
(b) providing a taste-modifying substance to the patient; and
(c) reducing the salty taste of the gastrointestinal tract preparation composition by at least 20% compared to the salty taste of the gastrointestinal tract preparation composition had the taste-modifying substance not been provided, by administering orally the gastrointestinal tract preparation composition to the patient from about 1 minute to about 1 hour after step (b).
2. The method of claim 1 , wherein the gastrointestinal tract is the intestine and the gastrointestinal tract preparation composition is a bowel preparation solution.
3. The method of claim 2 , wherein the intestine is the colon.
4. The method of claim 1 , wherein the gastrointestinal tract is cleansed prior to carrying out a diagnostic, therapeutic and/or surgical procedure on the patient.
5. The method of claim 1 , wherein the gastrointestinal tract is cleansed prior to an endoscopy.
6. The method of claim 5 , wherein the endoscopy is a colonoscopy or sigmoidoscopy.
7. The method of claim 1 , wherein the gastrointestinal tract is cleansed prior to a barium enema examination, capsule endoscopy, colon surgery or gastrointestinal tract surgery.
8. The method of claim 1 , wherein the taste-modifying substance is a sour taste-modifying agent.
9. The method of claim 8 , wherein the sour taste-modifying agent is miraculin.
10. The method of claim 9 , wherein miraculin comprises miracle fruit, flesh of miracle fruit, miracle fruit granules, miracle berry, miracle berry extracts, miracle fruit tablets, miracle berry tablets, or miraculin produced by a genetically modified organism.
11. The method of claim 1 , wherein the taste-modifying substance is selected from the group consisting of thaumatin, monellin, mabinlin, brazzein, pentadin, curculin, neuculin, miraculin and mixtures thereof.
12. The method of claim 1 , wherein the taste-modifying substance is provided in the form of a capsule, a tablet, a pill, granules, powders, a pellet, a solids mixture, a solution, a dispersion, an emulsion, a paste, an extract, or an isolate from a natural source.
13. The method of claim 1 , wherein the taste-modifying substance is provided from about 5 minutes to about 30 minutes before the gastrointestinal tract preparation composition is administered.
14. The method of claim 13 , wherein the taste-modifying substance is provided from about 10 minutes to about 15 minutes before the gastrointestinal tract preparation composition is administered.
15. The method of claim 1 , wherein the salty taste of the gastrointestinal tract preparation composition is reduced by at least about 30%.
16. The method of claim 15 , wherein the salty taste of the gastrointestinal tract preparation composition is reduced by at least about 50%.
17. The method of claim 16 , wherein the salty taste of the gastrointestinal tract preparation composition is reduced by at least about 70%.
18. The method of claim 1 , wherein the step to determine the pH of the gastrointestinal tract preparation composition is carried out prior to or after the step of providing a taste-modifying substance to the patient.
19. The method of claim 1 , wherein the pH ranges from about 4 to about 6.4.
20. The method of claim 1 , wherein the pH is about 4.8.
21. The method of claim 1 , wherein the pH of the gastrointestinal tract preparation composition is adjusted by at least an inorganic acid or an organic acid.
22. The method of claim 21 , wherein the acid is selected from the group consisting of citric acid, acetic acid, ascorbic acid, phosphoric acid, malic acid, succinic acid, formic acid, fumaric acid, maleic acid, or mixtures thereof.
23. The method of claim 1 , wherein the pH of the gastrointestinal tract preparation composition is adjusted by a compound selected from the group of ammonium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, carbon dioxide, and mixtures thereof.
24. The method of claim 1 , wherein the gastrointestinal tract preparation composition comprises a potassium salt, a sodium salt, a calcium salt, an ammonium salt or mixtures thereof.
25. The method of claim 1 , wherein the gastrointestinal tract preparation composition comprises at least one sodium phosphate.
26. The method of claim 1 , wherein the gastrointestinal tract preparation composition comprises sodium chloride, potassium chloride, and sodium bicarbonate (sodium hydrogen carbonate), sodium sulfate or mixtures thereof.
27. The method of claim 1 , wherein the gastrointestinal tract preparation composition comprises at least one alkali metal salt, and/or at least one alkaline earth metal salt.
28. The method of claim 27 , wherein the alkali metal is sodium or potassium.
29. The method of claim 27 , wherein the alkaline earth metal is magnesium or calcium.
30. The method of claim 1 , wherein the gastrointestinal tract preparation composition is a solution, and wherein the volume of the gastrointestinal tract preparation composition ranges from about 0.1 liters to about 5 liters.
31. The method of claim 30 , wherein the volume of the gastrointestinal tract preparation composition ranges from about 1 liter to about 4 liters.
32. The method of claim 1 , wherein the gastrointestinal tract preparation composition comprises polyethylene glycol (PEG).