IP Library › Granted Patent US 8,906,851
Granted Patent B2
US 8,906,851 · App. 13/708,474 · Granted Dec 9, 2014

Method for treating diabetes

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Quick Facts
Patent No.
US 8,906,851
App. No.
13/708,474
Granted
Dec 9, 2014
Kind
B2
Abstract

Methods for reducing body weight, altering body composition, treating diabetes, reducing HbA 1c and reducing average daily blood glucose by the use of exendins, exendin agonists or exendin analog agonists are provided.

Claims (8)

1. A method for treating diabetes in a human in need thereof comprising administering once weekly to the human a therapeutically effective amount of a pharmaceutical composition comprising exendin-4 to achieve a mean steady state plasma concentration of the exendin-4 of at least 170 pg/ml for at least one month in the human to treat diabetes, wherein the pharmaceutical composition further comprises a sugar.

2. The method of claim 1 , wherein the exendin 4 is present in the pharmaceutical composition in an amount of 1.0 mg to 5.0 mg.

3. The method of claim 1 , wherein the pharmaceutical composition comprises 5% (w/w) exendin-4, 2% (w/w) sucrose, and 93% (w/w) poly(lactide-co-glycolide)copolymer.

4. The method of claim 1 , wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 600 pg/ml.

5. The method of claim 1 , wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 350 pg/ml.

6. The method of claim 1 , wherein the mean steady state plasma concentration of exendin 4 is 170 pg/ml to 290 pg/ml.

7. The method of claim 1 , wherein the diabetes is type 2 diabetes.

8. The method of claim 1 , wherein the diabetes is type 1 diabetes.