Methods of treating hypertriglyceridemia
View Patent ↗In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
1. A method of reducing triglycerides in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl comprising, administering orally to the subject 4 capsules per day, each capsule comprising about 900 mg to about 1 g of ethyl eicosapentaenoate and not more than about 3% docosahexaenoic acid or its esters, by weight of total fatty acids present, for a period of 12 weeks to effect a reduction in triglycerides in the subject.
2. The method of claim 1 wherein the subject has a fasting baseline LDL-C from about 50 mg/dl to about 300 mg/dl.
3. The method of claim 1 , wherein the subject has one or more of: a baseline fasting non-HDL-C of about 200 mg/dl to about 400 mg/dl, a baseline fasting total cholesterol of about 250 mg/dl to about 400 mg/dl, a baseline fasting VLDL-C of about 140 mg/dl to about 200 mg/dl, and/or a baseline fasting HDL-C of about 10 mg/dl to about 60 mg/dl.
4. The method of claim 1 , wherein said administering effects a reduction in fasting triglycerides of at least about 10% without increasing LDL-C by more than 5% in the subject.
5. The method of claim 1 , wherein said administering effects a reduction in apolipoprotein B in the subject.
6. The method of claim 1 , wherein said administering effects a reduction in VLDL-C in the subject.
7. The method of claim 1 , wherein said administration effects reduction in fasting triglycerides of at least about 20% without increasing LDL-C in the subject.
8. The method of claim 1 , wherein each capsule comprises about 950 mg of ethyl eicosapentaenoate.
9. The method of claim 1 , wherein each capsule comprises about 975 mg of ethyl eicosapentaenoate.
10. The method of claim 1 , wherein each capsule comprises about 1 g of ethyl eicosapentaenoate.
11. A method of reducing triglycerides in a subject having a fasting baseline triglyceride level of 500 mg/dl to about 1500 mg/dl comprising, administering orally to the subject 4 capsules per day, each capsule comprising about 900 mg to about 1 g of ethyl eicosapentaenoate and not more than about 3% docosahexaenoic acid or its esters, by weight of total fatty acids present, for a period of 12 weeks to effect a reduction in triglycerides in the subject compared to placebo control.
12. The method of claim 11 wherein the subject has a fasting baseline LDL-C from about 50 mg/dl to about 300 mg/dl.
13. The method of claim 11 , wherein the subject has one or more of: a baseline fasting non-HDL-C of about 200 mg/dl to about 400 mg/dl, a baseline fasting total cholesterol of about 250 mg/dl to about 400 mg/dl, a baseline fasting VLDL-C of about 140 mg/dl to about 200 mg/dl, and/or a baseline fasting HDL-C of about 10 mg/dl to about 60 mg/dl.
14. The method of claim 11 , wherein said administering effects a reduction in fasting triglycerides of at least about 10% without increasing LDL-C by more than 5% in the subject compared to placebo control.
15. The method of claim 11 , wherein said administering effects a reduction in apolipoprotein B in the subject compared to placebo control.
16. The method of claim 11 , wherein said administering effects a reduction in VLDL-C in the subject compared to placebo control.
17. The method of claim 11 , wherein said administering effects reduction in fasting triglycerides of at least about 20% without increasing LDL-C in the subject compared to placebo control.
18. The method of claim 11 , wherein each capsule comprises about 950 mg of ethyl eicosapentaenoate.
19. The method of claim 11 , wherein each capsule comprises about 975 mg of ethyl eicosapentaenoate.
20. The method of claim 11 , wherein each capsule comprises about 1 g of ethyl eicosapentaenoate.