Silicone hydrogel lenses with convertible comfort agents

1. A method for making silicone hydrogel contact lenses, comprising the steps of:

(a) obtaining a mold having a first mold half and a second mold half, wherein the first mold half includes a first molding surface and the second mold half includes a second molding surface, wherein the first and second mold halves are configured to receive each other such that a lens-forming cavity is formed between the first molding surface and the second molding surface;

(b) dispensing a silicone hydrogel lens-forming material into the lens-forming cavity of the mold, wherein the silicone-hydrogel lens-forming material comprises a non-crosslinkable hydrolyzable polymer and at least one member selected from the group consisting of a silicone-containing monomer, a silicone-containing macromer, a silicone-containing prepolymer, and a mixture thereof, wherein the non-crosslinkable hydrolyzable polymer is selected from the group consisting of hydroxylpropylmethylcellulose phthalate, cellulose acetate phthalate, poly(butadiene/maleic anhydride), and combination thereof;

(c) curing the lens-forming material within the lens-forming cavity to form a silicone hydrogel contact lens containing the non-crosslinkable hydrolyzable polymer; and

(d) converting the non-crosslinkable hydrolyzable polymer in the silicone hydrogel contact lens into hydrophilic polymer, whereby the hydrophilic polymer in the silicone hydrogel contact lens is capable of imparting the silicone hydrogel contact lens a hydrophilic surface without post-curing surface treatment.

2. The method of claim 1 , wherein the mold is reusable and the curing step is performed by means of a spatial limitation of actinic radiation.

3. The method of claim 1 , wherein the non-crosslinkable hydrolyzable polymer is hydrolyzed into the hydrophilic polymer in a primary package containing the silicone hydrogel contact lens during autoclave.

4. The method of claim 1 , wherein the non-crosslinkable hydrolyzable polymer has a number-average molecular weight of from about 5,000 to about 1,000,000 daltons.

5. The method of claim 4 , wherein the non-crosslinkable hydrolyzable polymer is poly(butadiene/maleic anhydride).

6. The method of claim 4 , wherein the non-crosslinkable hydrolyzable polymer is hydroxylpropylmethylcellulose phthalate.

7. The method of claim 4 , wherein the non-crosslinkable hydrolyzable polymer is cellulose acetate phthalate.

8. The method of claim 2 , wherein the non-crosslinkable hydrolyzable polymer is hydrolyzed into the hydrophilic polymer in a primary package containing the silicone hydrogel contact lens during autoclave.

9. The method of claim 2 , wherein the non-crosslinkable hydrolyzable polymer has a number-average molecular weight of from about 5,000 to about 1,000,000 daltons.

10. The method of claim 9 , wherein the non-crosslinkable hydrolyzable polymer is poly(butadiene/maleic anhydride).

11. The method of claim 9 , wherein the non-crosslinkable hydrolyzable polymer is hydroxylpropylmethylcellulose phthalate.

12. The method of claim 9 , wherein the non-crosslinkable hydrolyzable polymer is cellulose acetate phthalate.

13. The method of claim 9 , wherein the non-crosslinkable hydrolyzable polymer has a number-average molecular weight of from about 5,000 to about 1,000,000 daltons.

14. The method of claim 13 , wherein the non-crosslinkable hydrolyzable polymer is poly(butadiene/maleic anhydride).

15. The method of claim 13 , wherein the non-crosslinkable hydrolyzable polymer is hydroxylpropylmethylcellulose phthalate.

16. The method of claim 13 , wherein the non-crosslinkable hydrolyzable polymer is cellulose acetate phthalate.