Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders
View Patent ↗A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.
1. A method for responding to a neurological disorder in a human patient comprising:
generating, by an implantable device, a signal representative of a cerebral perfusion measurement;
receiving and processing, by the implantable device, at predetermined times, a cerebral perfusion measurement;
automatically identifying, by the implantable device, a condition in the signal, wherein the condition comprises a predetermined change in cerebral perfusion;
identifying, by the implantable device, a structure in a first hemisphere, monitoring, by the implantable device, the first hemisphere for increased blood flow; and
automatically performing an action, by the implantable device, wherein the action comprises generating an instruction for therapy based on the identified change in the cerebral perfusion, wherein the therapy comprises stimulating a neural structure in a second hemisphere that is contralateral to the first hemisphere.
2. The method of claim 1 , wherein the therapy is intended to return the cerebral perfusion measurement to a desired value or range of values.
3. The method of claim 1 , further comprising:
continuously monitoring the signal; and
identifying, with an algorithm, a predetermined change in the cerebral perfusion, wherein the algorithm uses at least one of a control law or a threshold comparison to determine whether to cause an instruction to provide responsive therapy.
4. The method of claim 1 , wherein the therapy is adapted to modulate the cerebral perfusion by modulating at least one of electrical activity or chemical activity in the brain.
5. The method of claim 1 , further comprising:
acquiring an oximetry measurement.
6. The method of claim 5 , further comprising:
delivering optical stimulation as a therapy in response to the identified condition and upon receiving an optical stimulation delivery instruction.
7. The method of claim 1 , further comprising:
acquiring an electromagnetic field measurement.
8. The method of claim 7 , further comprising:
delivering electromagnetic stimulation as a therapy in response to the identified condition and upon receiving an electromagnetic stimulation delivery instruction.
9. The method of claim 1 , further comprising:
acquiring a temperature measurement.
10. The method of claim 9 , further comprising:
delivering thermal stimulation as a therapy to cool or heat a region of the patient's brain in response to the identified condition and upon receiving a thermal stimulation delivery instruction.
11. The method of claim 1 , further comprising:
delivering ultrasonic wave to a region of the patient's brain through a component adapted to deliver ultrasonic waves.
12. The method of claim 1 , further comprising:
acquiring a measurement of oxygen concentration.
13. The method of claim 1 , further comprising:
measuring, by an electrode, electrical impedance.
14. The method of claim 1 , further comprising:
measuring an electro graphic signal.
15. The method of claim 1 , further comprising:
delivering electrical stimulation through a stimulation electrode.
16. The method of claim 1 , wherein the condition further comprises:
a representation of cortical depression.
17. The method of claim 1 , wherein the condition further comprises:
a representation of oxygen availability.