Contact lenses containing carotenoid and method for making same
View Patent ↗The instant invention pertains to a method for producing contact lenses with improved oxidative stability of Carotenoids in the contact lens. The method of the invention involves adding a vitamin E material into a contact lens in an amount sufficient to reduce oxidative degradation of Carotenoids in the lens by at least about 30% in comparison with an identical contact lens without the vitamin E material.
1. A method for preparing a contact lens, comprising the steps of:
(a) obtaining a contact lens,
(b) immersing the contact lens in a solution containing a carotenoid and a vitamin E material; for a period of time sufficient to load a desired amount of a carotenoid and a vitamin E material; and
(c) autoclaving the contact lens of step (b) to sterilize the contact lens, wherein the contact lens has a lower oxidative degradation of carotenoids during lens autoclave and/or lens storage by at least about 30% in comparison to an identical contact lens without the vitamin E material.
2. The method of claim 1 wherein the contact lens comprises a hydrophilic silicon-containing polymer.
3. The method of claim 1 wherein the vitamin E material is selected from the group consisting of vitamin E, salts of vitamin E, derivatives of vitamin E and mixtures thereof.
4. The method of claim 1 wherein the carotenoid is selected from the group consisting of Beta-Carotene, lycopene, astaxanthin, Lutein and mixtures thereof.
5. The method of claim 1 wherein the carotenoid is Beta-Carotene.
6. The method of claim 1 in step (b) wherein the contact lens are immersed in the solution of vitamin E material and Carotenoid containing about 0.0005 wt % to 0.1 wt % by weight of Carotenoid and 0.05 wt % to 0.5 wt % of vitamin E.
7. The method of claim 1 wherein the contact lens comprises the vitamin E in an amount of from 50 μg to 250 μg and the Carotenoid in amount of 0.5 μg to 50 μg.
8. A contact lens, comprising: a formed water swellable, polymeric lens body; a carotenoids and a vitamin E material, wherein the vitamin E material is present in an amount sufficient to reduce oxidative degradation of the carotenoids during lens autoclave and/or lens storage by at least about 30% in comparison to an identical contact lens without the vitamin E material.
9. The contact lens of claim 8 , wherein polymeric lens body comprises a hydrophilic silicon-containing polymer.
10. The contact lens of claim 8 , wherein the vitamin E material is selected from the group consisting of vitamin E, salts of vitamin E, derivatives of vitamin E and mixtures thereof.
11. The contact lens of claim 8 , wherein the carotenoid is selected from the group consisting of Beta-Carotene, lycopene, astaxanthin, Lutein and mixtures thereof.
12. The contact lens of claim 9 wherein the carotenoid is Beta-Carotene.
13. The contact lens of claim 8 , wherein the contact lens comprises the vitamin E in an amount of from 50 μg to 250 μg and carotenoid in an amount of from 0.5 μg to 50 μg.
14. The contact lens of claim 8 , wherein the contact lens comprises carotenoid in an amount of from 0.5 μg to 5 μg.