MRI-guided medical interventional systems and methods

1. An MRI-guided interventional system for use with a body of patient and an interventional device, the system including:

a trajectory guide frame for guiding the interventional device with respect to a body of a patient in an MRI-guided procedure, the trajectory guide frame including:

a base having a patient access aperture therein, wherein the base is configured to be secured to the body of the patient;

a platform mounted on the base and including a support table and a moving plate that is translatable relative to the support table and the base along a translational axis;

a targeting cannula mounted on the moving plate for movement therewith relative to the support table and the base, the targeting cannula including an elongate guide bore therethrough, the guide bore defining a trajectory axis and being configured to guide placement of the interventional device in vivo; and

a stabilizer mechanism operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base;

wherein the trajectory guide frame is operable to translate the moving plate and thereby the targeting cannula along the translational axis relative to the base to position the trajectory axis to a desired intrabody trajectory to guide placement of the interventional device in vivo; and

wherein the translational axis is transverse to the trajectory axis.

2. The system of claim 1 including an elongate interventional device configured to be serially inserted along the trajectory axis through the guide bore and into the body of the patient in vivo.

3. The system of claim 1 wherein:

the translational axis is an X-translational axis;

the moving plate is translatable relative to the support table and the base along a Y-translational axis transverse to the X-translational axis; and

the Y-translational axis is transverse to the trajectory axis.

4. The system of claim 1 further including a yoke movably mounted on the base and rotatable relative to the base about a pivot axis, wherein the platform is mounted on the yoke for rotation therewith and the platform is configured to permit translational movement of the moving plate with respect to the yoke.

5. The system of claim 1 wherein:

the stabilizer mechanism includes an adjustment device and a rub bar; and

the rub bar and the support table cooperatively define a slot through which the moving plate slides in contact with the rub bar.

6. The system of claim 5 wherein the adjustment device includes a loading device operable to apply a load to the rub bar to compressively load the moving plate in the slot between the support table and the rub bar.

7. The system of claim 5 wherein the loading device includes at least one screw.

8. A trajectory guide frame for guiding an interventional device with respect to a body of a patient in an MRI-guided procedure, the trajectory guide frame comprising:

a base having a patient access aperture therein, wherein the base is configured to be secured to the body of the patient;

a platform mounted on the base and including a support table and a moving plate that is movable relative to the support table and the base;

a targeting cannula mounted on the moving plate for movement therewith relative to the support table and the base, the targeting cannula including a guide bore therethrough that is configured to guide placement of the interventional device in vivo; and

a stabilizer mechanism operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base;

wherein:

the stabilizer mechanism includes an adjustment device and a rub bar; and

the rub bar and the support table cooperatively define a slot through which the moving plate slides in contact with the rub bar.

9. The trajectory guide frame of claim 8 wherein the adjustment device is operable to apply a load to the rub bar to compressively load the moving plate in the slot between the support table and the rub bar.

10. The trajectory guide frame of claim 8 wherein the loading device includes at least one screw.

11. A method of adjusting a trajectory of an in vivo interventional device, comprising:

affixing a trajectory guide frame to a body of a patient in an MRI-guided procedure, the trajectory guide frame including:

a base having a patient access aperture therein, wherein the base is configured to be secured to the body of the patient;

a platform mounted on the base and including a support table and a moving plate that is translatable relative to the support table and the base along a translational axis;

a targeting cannula mounted on the moving plate for movement therewith relative to the support table and the base, the targeting cannula including an elongate guide bore therethrough, the guide bore defining a trajectory axis and being configured to guide placement of the interventional device in vivo; and

a stabilizer mechanism operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base;

wherein the trajectory guide frame is operable to translate the moving plate and thereby the targeting cannula along the translational axis relative to the base; and

wherein the translational axis is transverse to the trajectory axis; and

while the patient remains in position in a magnetic field associated with an MRI scanner, adjusting the trajectory guide frame to translate the moving plate and thereby the targeting cannula along the translational axis relative to the base to position the trajectory axis to a desired intrabody trajectory to guide placement of the interventional device in vivo.

12. The method of claim 11 wherein:

the stabilizer mechanism includes an adjustment device and a rub bar;

the rub bar and the support table cooperatively define a slot through which the moving plate slides in contact with the rub bar;

the adjustment device includes a loading device operable to apply a load to the rub bar to compressively load the moving plate in the slot between the support table and the rub bar; and

the method includes selectively operating the loading device to change the compressive load on the moving plate.

13. An MRI-guided interventional system, comprising:

a trajectory guide frame with a cooperating targeting cannula, wherein the trajectory guide frame is configured to translate and rotate such that the targeting cannula can be positioned to a desired intrabody trajectory, and wherein the targeting cannula includes a guide bore therethrough that is configured to guide placement of an interventional device in vivo, wherein the trajectory guide frame comprises:

a base having a patient access aperture formed therein, wherein the base is configured to be secured to the body of a patient;

a yoke movably mounted to the base and rotatable about a roll axis;

a platform movably mounted to the yoke and rotatable about a pitch axis, wherein the platform comprises an X-Y support table and a moving plate, wherein the moving plate is movably mounted to the support table to move in an X-direction and Y-direction relative to the base; and

a stabilizer mechanism operable to selectively control movement between the X-Y support table and the moving plate to stabilize a position of the targeting cannula with respect to the base.

14. The system of claim 13 including at least one user-activatable actuator operably connected to the trajectory guide frame and configured to translate and rotate the trajectory guide frame relative to the body of the patient so as to position the targeting cannula to a desired intrabody trajectory.