IP Library › Patent Application 13721662
Patent Application
App. No. 13/721,662

In Vivo Activation of Antigen Presenting Cells for Enhancement of Immune Responses Induced by Virus Like Particles

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Quick Facts
Patent No.
US None
App. No.
13/721,662
Abstract

The invention relates to the finding that stimulation of antigen presenting cell (APC) activation using substances such as anti-CD40 antibodies or DNA oligomers rich in non-methylated C and G (CpGs) can dramatically enhance the specific T cell response obtained after vaccination with recombinant virus like particles (VLPs) coupled, fused or otherwise attached to antigens. While vaccination with recombinant VLPs fused to a cytotoxic T cell (CTL) epitope of lymphocytic choriomeningitis virus induced low levels cytolytic activity only and did not induce efficient anti-viral protection, VLPs injected together with anti-CD40 antibodies or CpGs induced strong CTL activity and full anti-viral protection. Thus, stimulation of APC-activation through antigen presenting cell activators such as anti-CD40 antibodies or CpGs can exhibit a potent adjuvant effect for vaccination with VLPs coupled, fused or attached otherwise to antigens.

Claims (5)

1 . A composition for enhancing an immune response against an antigen in an animal comprising:

(a) a virus-like particle bound to at least one antigen capable of inducing an immune response against said antigen in said animal;

and

(b) at least one substance that activates antigen presenting cells in an amount sufficient to enhance the immune response of said animal to said antigen.

2 - 194 . (canceled)