PLOD-2 stimulators and their use in the treatment of skin
Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a composition comprising an effective amount of N-Acetyl-Tyrosinamide and an effective amount of a retinoid, in a cosmetically acceptable vehicle, for topical application to the skin for a time sufficient to improve the appearance of said skin.
1. A method for treatment of fine lines and/or wrinkles in human skin comprising topically applying to an area of the skin in need thereof a composition comprising:
an effective amount of N-Acetyl-Tyrosinamide and
an effective amount of a retinoid,
for a time sufficient to reduce the severity of said fine lines and/or wrinkles.
2. The method according to claim 1 , wherein said composition is applied to said skin at least once daily for a period of at least four weeks.
3. The method according to claim 1 , further comprising topically applying to said area of the skin in need thereof an effective amount of glycolic acid.
4. The method according to claim 1 , further comprising topically applying to said area of the skin in need thereof an effective amount of salicylic acid.
5. The method according to claim 1 , wherein said composition further comprises:
water,
glycerin,
ethylhexyl isononanoate,
octyldodecanol,
dimethicone,
butylene glycol,
polymethyl methacrylate,
trisiloxane,
hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer,
isohexadecane,
ascorbic acid,
BHT,
PEG-100 Stearate,
Laureth-4,
Polysorbate-60,
Dimethiconol,
Polysorbate-20,
Sodium hydroxide,
Disodium EDTA,
a preservative, and
optionally, a fragrance.