Phenoxymethyl heterocyclic compounds
View Patent ↗Phenoxymethyl compounds that inhibit at least one phosphodiesterase 10 are described as are pharmaceutical compositions containing such compounds an methods for treating various CNS disorders by administering such compounds to a patient in need thereof.
1. A method for treating a central nervous system (CNS) disorder selected from the group consisting of Huntington's disease, schizophrenia, a schizo-affective condition, obsessive compulsive disorder and psychosis associated with Parkinson's disease, the method comprising administering to a human in need thereof a therapeutically effective amount of 4-(4-(imidazo[1,2-b]pyridazin-2-ylmethoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the CNS disorder is psychosis associated with Parkinson's disease.
3. The method of claim 1 , wherein the CNS disorder is schizophrenia or schizo-affective condition.
4. The method of claim 1 , wherein the CNS disorder is Huntington's disease.
5. The method of claim 1 , wherein the CNS disorder is obsessive compulsive disorder.
6. A method for treating a CNS disorder selected from the group consisting of Huntington's disease, schizophrenia, a schizo-affective condition, obsessive compulsive disorder and psychosis associated with Parkinson's disease, the method comprising administering to a human in need thereof a therapeutically effective amount of a pharmaceutical composition comprising:
(i) 4-(4-(imidazo[1,2-b]pyridazin-2-ylmethoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one or a pharmaceutically acceptable salt thereof; and
(ii) a pharmaceutically acceptable carrier or excipient.
7. The method of claim 6 , wherein the CNS disorder is psychosis associated with Parkinson's disease.
8. The method of claim 6 , wherein the CNS disorder is schizophrenia or schizo-affective condition.
9. The method of claim 6 , wherein the CNS disorder is Huntington's disease.
10. The method of claim 6 , wherein the CNS disorder is obsessive compulsive disorder.