Hepatitis B antiviral agents
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
1. A compound of Formula IVc:
or a pharmaceutically acceptable salt thereof;
wherein X is halo;
G 1 is halo;
G 2 is C 1 -C 4 alkyl, or halo; and
G 4 is H, halo, C 1 -C 4 alkyl, or OH.
2. A pharmaceutical composition comprising a compound according to claim 1 , or a salt, solvate or N-oxide-thereof and at least one pharmaceutically acceptable carrier.
3. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
16. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
17. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
18. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
19. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
20. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
21. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.
22. The compound of claim 1 , wherein the compound of Formula IVc is:
or a pharmaceutically acceptable salt thereof.