Methods of isolating (4-chloro-2-fluoro-3-substituted-phenyl)boronates and methods of using the same
View Patent ↗Methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate include adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas or carbon dioxide solid (dry ice) and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid. The precipitated solid may be removed from the mixture. Methods of using 4-chloro-2-fluoro-3-substituted-phenylboronates to produce methyl-4-amino-3-chloro-6-(4-chloro-2-fluoro-3-substituted-phenyl)pyridine-2-carboxylates are also disclosed. A 4-chloro-2-fluoro-3-substituted-phenylboronate produced by one of the methods of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate is also disclosed, wherein the 4-chloro-2-fluoro-3-substituted-phenylboronate may be obtained at a yield of greater than or equal to about 90%.
1. A method of isolating a 4-chloro-2-fluoro-3-substituted-phenylboronate, comprising:
adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt to react the at least one lithium salt with the carbon dioxide gas and form a mixture comprising the 4-chloro-2-fluoro-3-substituted-phenylboronate, the inert organic solvent, and a precipitated solid; and removing the precipitated solid from the mixture.
2. The method of claim 1 , wherein adding carbon dioxide gas comprises bubbling carbon dioxide gas through the solution of 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt.
3. The method of claim 1 , wherein adding carbon dioxide gas or carbon dioxide solid (dry ice) to a solution comprising a 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt comprises adding carbon dioxide gas to a solution comprising dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, 1,2-dimethoxyethane, and at least one lithium salt.
4. The method of claim 2 , wherein removing the precipitated solid from the mixture comprises recovering dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate in 1,2-dimethoxyethane.
5. The method of claim 3 , wherein recovering dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate in 1,2-dimethoxyethane comprises obtaining a yield of dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate of greater than or equal to about 90%.
6. A method of synthesizing and isolating dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, comprising:
contacting a solution comprising 2-chloro-6-fluoroanisole and 1,2-dimethoxyethane with n-butyl lithium to form a reaction mixture comprising 6-chloro-2-fluoro-3-lithioanisole and the 1,2-dimethoxyethane;
contacting the reaction mixture with trimethyl borate to form a salinated phenyl boronate solution comprising dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, the 1,2-dimethoxyethane, and at least one lithium salt;
introducing carbon dioxide gas or carbon dioxide solid (dry ice) to the salinated phenyl boronate solution to form a mixture comprising the dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, the 1,2-dimethoxyethane, and lithium methyl carbonate; and
separating the lithium methyl carbonate to form a desalinated phenyl boronate solution comprising the dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate and the 1,2-dimethoxyethane.
7. The method of claim 6 , wherein introducing carbon dioxide comprises bubbling carbon dioxide gas through the solution of 4-chloro-2-fluoro-3-substituted-phenylboronate, an inert organic solvent, and at least one lithium salt.
8. The method of claim 6 , wherein separating the lithium methyl carbonate to form a desalinated phenyl boronate solution comprising dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, 1,2-dimethoxyethane, and lithium methyl carbonate comprises obtaining a yield of dimethyl 4-chloro-2-fluoro-3-methoxyphenylboronate, of greater than or equal to about 90%.
9. The method of claim 8 , further comprising using the desalinated phenyl boronate solution without concentration or drying.