Compositions of human lipids and methods of making and using same
The disclosure features methods of making compositions that include a human lipid. The methods can include: obtaining whole human milk; separating the milk into a cream portion and a skim portion; processing the cream portion; and pasteurizing the processed cream portion.
1. A method of making a composition comprising a human lipid, the method comprising:
(a) obtaining whole human milk;
(b) separating the milk into a cream portion and a skim portion;
(c) purifying the cream portion obtained in step (b) to obtain a composition comprising a human lipid;
(d) pasteurizing the composition comprising a human lipid; and
(e) parenterally administering the composition comprising a human lipid obtained in step (c) to a human subject.
2. The method of claim 1 wherein the purifying comprises diafiltration.
3. The method of claim 1 further comprising adding one or more constituents to the composition obtained in step (d) selected from the group consisting of an emulsifier, a preservative, a diluents, and an osmolality modifier.
4. The method of claim 3 , wherein the preservative is an antioxidant.
5. The method of claim 4 , wherein the antioxidant is selected from the group consisting of alpha-tocopherol, vitamin C, a carotenoid, and a retinoid.
6. The method of claim 3 , wherein the osmolality modifier comprises glycerin.
7. The method of claim 1 further comprising adding one or more constituents to the compostion obtained in step (d) selected from the group consisting of a vitamin, a mineral and a carbohydrate.
8. The method of claim 1 wherein the subject has a nutritional disease or disorder.
9. The method of claim 1 wherein the subject is a premature infant.