PRE-FILLED FLUID CARTRIDGE AND FILLING METHODS
Disclosed are cartridge filling systems and methods that can include providing a vial body defining a vial lumen, providing a floating stopper positioned within the vial lumen, providing an end cap, where the proximal end of the end cap can abut the distal end of the floating stopper such that the floating stopper is prevented from moving distally within the vial lumen, filling at least a portion of the vial lumen with a fluid, and removing the end cap from the vial body after filling at least a portion of the vial lumen with a fluid.
1 . A cartridge comprising:
(a) a vial body defining a vial lumen, the vial body having a proximal end and a distal end;
(b) a flange positioned at about the proximal end of the vial body;
(c) a floating stopper positioned within the vial lumen defined by the vial body, the floating stopper having a proximal end and a distal end;
(d) an end cap, the end cap having a proximal end and a distal end, wherein the proximal end of the end cap abuts the distal end of the floating stopper such that the floating stopper is retained at a first position within the vial lumen.
2 . The cartridge of claim 1 , wherein the end cap is configured for removal from the vial body after at least a portion of the vial lumen is filled with a fluid.
3 . The cartridge of claim 1 , wherein the distal end of the end cap is configured to engage a filling tub.
4 . The cartridge of claim 1 , wherein the flange is configured to engage a tooling nest.
5 . The cartridge of claim 1 , wherein the proximal end of the vial body is configured to accept a fixed stopper.
6 . The cartridge of claim 5 , wherein a button is configured to engage the fixed stopper.
7 . The cartridge of claim 1 , wherein the floating stopper is formed from an elastomeric material.
8 . The cartridge of claim 1 , wherein the end cap is sized such that the vial lumen is filled with a predetermined amount of fluid.
9 . The cartridge of claim 8 , wherein the fluid is a medicament.
10 . A method of filling a cartridge comprising the steps of:
providing a vial body defining a vial lumen, the vial body having a proximal end and a distal end;
providing a floating stopper positioned within the vial lumen defined by the vial body, the floating stopper having a proximal end and a distal end;
providing an end cap, the end cap having a proximal end and a distal end, wherein the proximal end of the end cap abuts the distal end of the floating stopper such that the floating stopper is prevented from moving distally within the vial lumen;
filling at least a portion of the vial lumen with a fluid; and
removing the end cap from the vial body after filling at least a portion of the vial lumen with the fluid.
11 . The method of claim 10 , further comprising the step of engaging the distal end of the end cap with a filling tub prior to filling at least a portion of the vial lumen with a fluid.
12 . The method of claim 11 , further comprising the step of sealing the filling tub within a pouch.
13 . The method of claim 12 , further comprising the step of sterilizing the filling tub.
14 . The method of claim 10 , wherein the proximal end of the vial body is configured to accept a fixed stopper.
15 . The method of claim 14 , wherein a button is configured to engage the fixed stopper.
16 . The method of claim 10 , wherein the floating stopper is formed from an elastomeric material.
17 . The method of claim 10 , wherein the end cap is sized such that the vial lumen is filled with a predetermined amount of fluid.
18 . The method of claim 15 , wherein the fluid is a medicament.
19 . The method of claim 15 , wherein providing a vial body, providing an end cap, and providing a floating stopper occur prior to filling at least a portion of the vial lumen with the fluid.
20 . The method of claim 15 , further comprising the step of creating a vacuum in the vial lumen.