IP Library Granted Patent US 9,241,753
Granted Patent B2
US 9,241,753 · App. 13/741,350 · Granted Jan 26, 2016

Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments

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Quick Facts
Patent No.
US 9,241,753
App. No.
13/741,350
Granted
Jan 26, 2016
Kind
B2
Abstract

A cryogenic needle probe having a proximal and distal region. A cooling supply tube provides pressurized cooling fluid within the needle. The proximal region is more conductive that the distal region. The proximal region is conductively coupled to a heat source.

Claims (24)

1. A method for cryogenically treating tissue, the method comprising:

providing a needle probe shaft having a distal portion and a proximal portion, the needle probe shaft comprising a first conductivity at the distal portion and a second conductivity at the proximal portion, wherein the proximal portion extends axially along a longitudinal axis of the needle probe shaft, and wherein the second conductivity is greater than the first conductivity;

advancing the needle probe shaft into non-target tissue layered above target tissue, such that the distal portion of the needle probe shaft is positioned within the target tissue and the proximal portion of the needle probe shaft is positioned within the non-target tissue

cooling the target tissue via the distal portion of the needle probe shaft to affect remodeling of the target tissue; and

directly conducting energy to the proximal portion of the needle probe shaft while cooling the target tissue, thereby limiting cooling of the non-target tissue.

2. The method of claim 1 , wherein the non-target tissues includes skin.

3. The method of claim 2 , wherein limiting cooling prevents discoloration of the skin.

4. The method of claim 2 , wherein the non-target tissues includes at least a portion of subcutaneous tissue.

5. The method of claim 1 , wherein cooling zones formed in the target tissue terminate proximally about a distal end of a second conductive material.

6. The method of claim 1 , wherein remodeling the tissue causes nerve signal conduction disruption within the target tissue.

7. The method of claim 1 , wherein the needle probe shaft comprises a first conductive material at the distal portion and a second conductive material at the proximal portion, wherein the second material is more conductive than the first material.

8. The method of claim 7 , wherein the second conductive material is conductively coupled to a heat source.

9. The method of claim 8 , wherein the heat source provides the second conductive material with 0.5-3 W during cooling.

10. The method of claim 7 , wherein conducting energy provides energy to affect a phase change of a liquid coolant to a gas at the proximal portion.

11. The method of claim 7 , wherein the first conductive material comprises stainless steel.

12. The method of claim 11 , wherein the second conductive material comprises at least one layer of metal over the stainless steel.

13. The method of claim 12 , wherein the at least one layer of metal comprises gold.

14. The method of claim 1 , wherein the proximal portion of the needle probe shaft has greater mass than the distal portion of the needle probe shaft.

15. The method of claim 14 , wherein the proximal portion of the needle probe shaft has a greater wall-thickness than the distal portion of the needle probe shaft.

16. A method for cryogenically treating tissue, the method comprising:

providing a needle probe shaft having a distal portion and a proximal portion, the needle probe shaft comprising a first conductive material and a cladding layer extending axially along a longitudinal axis of the needle probe shaft and along an outer surface of the proximal portion of the needle probe shaft, wherein the cladding layer comprises a second conductive material conductively coupled to the first material at the proximal portion, wherein the second material is more conductive than the first material;

advancing the needle probe shaft into non-target tissue layered above target tissue, such that the distal portion of the needle probe shaft is positioned within the target tissue and the cladding layer of the needle probe shaft is positioned within the non-target tissue

cooling the target tissue via the distal portion of the needle probe shaft to affect remodeling of the target tissue; and

directly conducting heat energy to the cladding layer of the needle probe shaft while cooling the target tissue, thereby limiting cooling of the non-target tissue.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Dec 5, 2025
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 073779/0532 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Mar 31, 2023
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 063214/0108 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 31, 2023
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 063213/0864 →
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Dec 14, 2021
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; FLEXION THERAPEUTICS, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 058516/0636 →
CONFIRMATORY ASSIGNMENT Recorded Jul 15, 2019
From: MYOSCIENCE, INC.
To: PACIRA CRYOTECH, INC.
Reel/Frame 049758/0028 →
RELEASE OF SECURITY INTEREST Recorded Feb 4, 2019
From: VENTURE LENDING & LEASING VII, INC.
To: MYOSCIENCE, INC.
Reel/Frame 048237/0168 →
CORRECTIVE ASSIGNMENT TO CORRECT TO REMOVE APPLICATION NUMBER 12160639 PREVIOUSLY RECORDED AT REEL: 034557 FRAME: 0073. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Dec 29, 2014
From: MYOSCIENCE, INC.
To: VENTURE LENDING & LEASING VII, INC.
Reel/Frame 034713/0226 →
SECURITY INTEREST Recorded Dec 19, 2014
From: MYOSCIENCE, INC.
To: VENTURE LENDING & LEASING VII, INC.
Reel/Frame 034557/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2013
From: FOURKAS, MICHAEL; WILLIAMS, RONALD; ALLISON, JOHN
To: MYOSCIENCE, INC.
Reel/Frame 030502/0988 →