IP Library Granted Patent US 9,155,584
Granted Patent B2
US 9,155,584 · App. 13/741,363 · Granted Oct 13, 2015

Cryogenic probe filtration system

Inventors: Michael Fourkas (Sunnyvale, CA); Eric Ryba (Redwood City, CA); Jesse Rosen (Redwood City, CA); Punit Govenji (Los Altos Hills, CA)
Assignee: MyoScience, Inc.
A61B18/02A61B2017/00473A61B2018/0262
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Quick Facts
Patent No.
US 9,155,584
App. No.
13/741,363
Granted
Oct 13, 2015
Kind
B2
Abstract

A cryogenic device having a filter device fluidly connected between a valve and a cooling fluid cartridge. The filter device filters solid and fluid impurities received from the cartridge. The filter device also captures fluid impurities from the cryogenic device when not in use.

Claims (35)

1. A cryogenic device comprising:

a handpiece portion having a cryogenic coolant pathway configured to fluidly couple to a detachable needle probe; and

a cartridge holder coupled to the handpiece portion and configured for removeably holding a pressurized cartridge; and

a filter device coupled to the cartridge holder, the filter device having a distal filter end for fluidly coupling the filter device to the cryogenic coolant pathway and a proximal filter end for fluidly coupling to the pressurized cartridge;

wherein the filter device comprises:

at least one particulate filter configured to filter particulates; and

a molecular filter configured to capture fluid contaminants received from the pressurized cartridge and from the coolant pathway when not in fluid communication with the pressurized cartridge,

wherein the cartridge holder further comprises a coupling assembly that has a sealing valve that seals the cryogenic coolant pathway from atmosphere when the pressurized cartridge is not coupled to the cartridge holder.

2. The cryogenic device of claim 1 , wherein each of the proximal filter end and the distal filter end includes at least one microscreen.

3. The cryogenic device of claim 1 , wherein the at least one microscreen is a 2 micron screen or less.

4. The cryogenic device of claim 1 , wherein the molecular filter comprises filter media.

5. The cryogenic device of claim 4 , wherein the filter media comprises a plurality of molecular sieves.

6. The cryogenic device of claim 5 , wherein the molecular sieves comprise pellets having pores ranging in size from 1-20 Å.

7. The cryogenic device of claim 6 , wherein average pore size is 5 Å.

8. The cryogenic device of claim 1 , wherein the proximal end of the filter assembly comprises a puncture coupling configured to puncture the pressurized cartridge.

9. The cryogenic device of claim 1 , wherein the cartridge holder comprises a cartridge receiver affixed to the handpiece and having a cavity for holding the pressurized cartridge.

10. The cryogenic device of claim 9 , wherein the cartridge holder further comprises a cartridge cover removeably attached to the cartridge receiver.

11. The cryogenic device of claim 10 , wherein the pressurized cartridge cover couples to the cartridge receiver in a first position where the pressurized cartridge is held intact by the cartridge receiver, and wherein the cover is moveable to a second position in which the pressurized cartridge is punctured and made fluidly coupled to the filter assembly.

12. The cryogenic device of claim 1 , wherein the coupling assembly includes a pressure relief valve.

13. The cryogenic device of claim 1 , wherein at least a portion of the cryogenic coolant pathway between the pressurized cartridge and the needle probe is hydrophobic and/or oleophobic.

14. The cryogenic device of claim 1 , wherein the coupling assembly is connected between the pressurized cartridge and filter device.

15. A cryogenic device comprising:

a handpiece portion having a cryogenic coolant pathway configured to fluidly couple to a detachable needle probe; and

a cartridge holder coupled to the handpiece portion and configured for removeably holding a pressurized cartridge; and

a filter device coupled to the cartridge holder, the filter device having a distal filter end for fluidly coupling the filter device to the cryogenic coolant pathway and a proximal filter end for fluidly coupling to the pressurized cartridge;

wherein the filter device comprises a filtration media that is modified to be hydrophobic or oleophobic,

wherein the cartridge holder further comprises a coupling assembly that has a sealing valve that seals the cryogenic coolant pathway from atmosphere when the cartridge is not coupled to the cartridge holder.

16. The cryogenic device of claim 15 , wherein the proximal end of the filter assembly comprises a puncture coupling configured to puncture the pressurized cartridge.

17. The cryogenic device of claim 15 , wherein the cartridge holder comprises a cartridge receiver affixed to the handpiece and having a cavity for holding the pressurized cartridge.

18. The cryogenic device of claim 17 , wherein the cartridge holder further comprises a cartridge cover removeably attached to the cartridge receiver.

19. The cryogenic device of claim 18 , wherein the cartridge cover couples to the cartridge receiver in a first position where the pressurized cartridge is held intact by the cartridge receiver, and wherein the cover is moveable to a second position in which the pressurized cartridge is punctured and made fluidly coupled to the filter assembly.

20. The cryogenic device of claim 15 , wherein the coupling assembly includes a pressure relief valve.

21. The cryogenic device of claim 15 , wherein at least a portion of the cryogenic coolant pathway between the pressurized cartridge and the needle probe is hydrophobic or oleophobic.

22. The cryogenic device of claim 15 , wherein the filtration media comprises surface modified ePTFE, sintered polyethylene, or metal mesh.

23. The cryogenic device of claim 15 , wherein the coupling assembly is connected between the pressurized cartridge and filter device.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Dec 5, 2025
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 073779/0532 →
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Mar 31, 2023
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 063214/0108 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 31, 2023
From: JPMORGAN CHASE BANK, N.A.
To: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; PACIRA THERAPEUTICS, INC. (F/K/A FLEXION THERAPEUTICS, INC.)
Reel/Frame 063213/0864 →
SUPPLEMENTAL CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Dec 14, 2021
From: PACIRA CRYOTECH, INC.; PACIRA PHARMACEUTICALS, INC.; FLEXION THERAPEUTICS, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 058516/0636 →
CONFIRMATORY ASSIGNMENT Recorded Jul 15, 2019
From: MYOSCIENCE, INC.
To: PACIRA CRYOTECH, INC.
Reel/Frame 049758/0028 →
RELEASE OF SECURITY INTEREST Recorded Feb 4, 2019
From: VENTURE LENDING & LEASING VII, INC.
To: MYOSCIENCE, INC.
Reel/Frame 048237/0168 →
CORRECTIVE ASSIGNMENT TO CORRECT TO REMOVE APPLICATION NUMBER 12160639 PREVIOUSLY RECORDED AT REEL: 034557 FRAME: 0073. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Dec 29, 2014
From: MYOSCIENCE, INC.
To: VENTURE LENDING & LEASING VII, INC.
Reel/Frame 034713/0226 →
SECURITY INTEREST Recorded Dec 19, 2014
From: MYOSCIENCE, INC.
To: VENTURE LENDING & LEASING VII, INC.
Reel/Frame 034557/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2013
From: FOURKAS, MICHAEL; RYBA, ERIC; ROSEN, JESSE; GOVENJI, PUNIT
To: MYOSCIENCE, INC.
Reel/Frame 030503/0481 →
Continuity (2)
Provisional Application 61586698 · Jan 13, 2012
Related Publication 20130184694A1 · Jul 18, 2013