Body cavity prosthesis

1. A prosthesis configured to engage intralumenal tissue when deployed within a body cavity, the prosthesis comprising:

an expandable frame comprising a first end and a second end and a longitudinal axis extending therethrough, the frame configured to radially expand and contract for deployment within the body cavity;

a plurality of first anchors each having a base connected to a first portion of the frame and a plurality of second anchors each having a base connected to a second portion of the frame, wherein the first portion is closer to the first end than the second portion is to the first end, and the second portion is closer to the second end than the first portion is to the second end, wherein the second portion of the frame comprises a plurality of foreshortening cells and the first portion of the frame comprises a plurality of longitudinally extending struts that are each connected to a foreshortening cell at a connection location and extend away from the foreshortening cells toward the first end in a direction generally parallel with the longitudinal axis;

wherein when the frame is in an expanded configuration:

outermost ends of the first anchors are positioned radially outward from the frame and extend generally toward the second end of the frame so that the outermost end of each first anchor is closer to the second end than the base of that first anchor is to the second end;

outermost ends of the second anchors are positioned radially outward from the frame and extend generally toward the first end of the frame in a direction substantially parallel with the longitudinal axis so that the outermost end of each second anchor is closer to the first end than the base of that second anchor is to the first end;

the outermost ends of the first anchors are axially spaced from the outermost ends of the second anchors; and

at least some of the first anchors comprise a first strut and a second strut extending radially outward from the frame and extending longitudinally along a length of the frame in a direction generally toward the second end, the first and second struts joining at a free apex at a location radially outward from the frame, wherein the base of the first anchors is longitudinally spaced away from the connection location such that the base of the first anchors is located closer to the first end of the frame than the connection location of the longitudinally extending struts to the foreshortening cells is to the first end; and

wherein the frame is configured such that radial expansion of the frame causes the first anchors and second anchors to draw closer together.

2. The prosthesis of claim 1 , wherein at least some of the first anchors further comprise a protuberance extending from the free apex in a direction generally toward the second end.

3. The prosthesis of claim 1 , wherein the free apex terminates in an end that extends longitudinally in a direction generally toward the second end.

4. The prosthesis of claim 1 , wherein at least some of the second anchors comprise a segment that extends generally radially outwardly from the frame and terminates in an end that extends longitudinally in a direction toward the first end in a direction substantially parallel with the longitudinal axis.

5. The prosthesis of claim 1 , wherein the outermost ends of the first anchors are circumferentially offset from the outermost ends of the second anchors when the frame is in an expanded configuration.

6. The prosthesis of claim 1 , further comprising a valve body attached to the frame.

7. The prosthesis of claim 1 , wherein at least some of the second anchors comprise an eyelet.

8. The prosthesis of claim 7 , further comprising fabric attached to the eyelets of the second anchors.

9. The prosthesis of claim 1 , further comprising fabric covering the frame and extending to at least part of the second anchors while following a contour of the second anchors.

10. The prosthesis of claim 1 , wherein the first strut, second strut, and free apex connect to form a rounded end of the first anchor.

11. The prosthesis of claim 1 , wherein the plurality of first anchors combine to form an undulating ring extending circumferentially around the frame.

12. The prosthesis of claim 1 , wherein the first strut and the second strut extend radially outward from the frame to form a V-shape when in the expanded configuration.

13. The prosthesis of claim 1 , wherein the first portion of the frame is a non-foreshortening portion that does not substantially foreshorten when the first portion of the frame is radially expanded.

14. The prosthesis of claim 1 , wherein the second portion of the frame is a foreshortening portion that substantially foreshortens when the second portion of the frame is radially expanded.

15. The prosthesis of claim 1 , wherein the frame, the plurality of first anchors and the plurality of second anchors are formed from a single cut tube.

16. The prosthesis of claim 1 , wherein the second portion of the frame comprises at least one circumferential ring of diamond-shaped foreshortening cells, each diamond-shaped foreshortening cell comprising four corners, and wherein a longitudinally extending strut extends from a corner of each of the foreshortening cells in the at least one circumferential ring.

17. The prosthesis of claim 16 , wherein the base of each of the plurality of second anchors is located at a corner of a foreshortening cell opposite a corner from which a longitudinally extending strut extends.

18. The prosthesis of claim 1 , further comprising a valve body attached to the frame, wherein the valve body can move between an open position wherein blood can flow from the first end toward the second end and a closed position which blocks blood from flowing from the second end toward the first end.

19. The prosthesis of claim 1 , wherein when the frame is in an expanded configuration, the free apices of the first anchors are closer to the first end of the frame than the connection location of the longitudinally extending struts to the foreshortening cells is to the first end.