NATURAL MARINE SOURCE PHOSPHOLIPIDS COMPRISING POLYUNSATURATED FATTY ACIDS AND THEIR APPLICATIONS
A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
1 .- 120 . (canceled)
121 . A method for preventing or treating coronary artery disease comprising administering to a patient in need thereof an effective amount of a composition comprising a phospholipid of the general formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue,
X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3 or
and
said composition is suitable for human consumption.
122 . The method of claim 121 , wherein said composition is contained in a capsule suitable for oral administration.
123 . The method of claim 121 , wherein composition further comprises an additional lipid selected from monoglycerides, triglycerides, cholesterols and mixtures thereof.
124 . The method of claim 121 , wherein said composition comprises polyunsaturated fatty acids in an amount of at least 15% w/w of the total lipids.
125 . The method of claim 124 , wherein said polyunsaturated fatty acids are omega-3 fatty acids.
126 . The method of claim 121 , wherein said composition comprises phospholipids in an amount of at least 40% w/w.
127 . The method of claim 121 , wherein said composition further comprises astaxanthin.
128 . The method of claim 121 , wherein said composition is derived from an aquatic or marine source.
129 . A method for preventing or treating hypercholesterolemia comprising administering to a patient in need thereof an effective amount of a composition comprising a phospholipid of the general formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue,
X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3 or
and
said composition is suitable for human consumption.
130 . The method of claim 129 , wherein said composition is contained in a capsule suitable for oral administration.
131 . The method of claim 129 , wherein composition further comprises an additional lipid selected from monoglycerides, triglycerides, cholesterols and mixtures thereof.
132 . The method of claim 129 , wherein said composition comprises polyunsaturated fatty acids in an amount of at least 15% w/w of the total lipids.
133 . The method of claim 132 , wherein said polyunsaturated fatty acids are omega-3 fatty acids.
134 . The method of claim 129 , wherein said composition comprises phospholipids in an amount of at least 40% w/w.
135 . The method of claim 129 , wherein said composition further comprises astaxanthin.
136 . The method of claim 129 , wherein said composition is derived from an aquatic or marine source.
137 . A method for preventing or treating hypertension comprising administering to a patient in need thereof an effective amount of a composition comprising a phospholipid of the general formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue,
X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3 or
and
said composition is suitable for human consumption.
138 . The method of claim 137 , wherein said composition is contained in a tablet or capsule suitable for oral administration.
139 . The method of claim 137 , wherein composition further comprises an additional lipid selected from monoglycerides, triglycerides, cholesterols and mixtures thereof.
140 . The method of claim 137 , wherein said composition comprises polyunsaturated fatty acids in an amount of at least 15% w/w of the total lipids.
141 . The method of claim 140 , wherein said polyunsaturated fatty acids are omega-3 fatty acids.
142 . The method of claim 137 , wherein said composition comprises phospholipids in an amount of at least 40% w/w.
143 . The method of claim 137 , wherein said composition further comprises astaxanthin.
144 . The method of claim 137 , wherein said composition is derived from an aquatic or marine source.
145 . A method for preventing or treating coronary artery disease comprising administering to a patient in need thereof an effective amount of a composition comprising a krill extract comprising a phospholipid of the formula (I),
wherein:
R1 and R2, each together with the respective carboxyl groups to which each is attached, each independently represents a docosahexaenoic acid (DHA) or an eicosapentaenoic acid (EPA) residue, and X is —CH 2 CH 2 NH 3 , —CH 2 CH 2 N(CH 3 ) 3, or
the extract is extracted under conditions suitable for preserving an effective amount of a phospholipid having two independently selected fatty acid chains within the same molecule selected from EPA and DHA;
the extract comprises phospholipids in an amount of at least 40% w/w;
the extract comprises omega-3 fatty acids in an amount of at least 15% w/w;
the extract comprises astaxanthin and
the extract is suitable for human consumption.