IP Library › Granted Patent US 8,618,147
Granted Patent B2
US 8,618,147 · App. 13/751,530 · Granted Dec 31, 2013

Modified macrophage migration inhibitory factor inhibitors

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Quick Facts
Patent No.
US 8,618,147
App. No.
13/751,530
Granted
Dec 31, 2013
Kind
B2
Abstract

Provided are various compounds of Formula I (I). Also provided are various compounds of Formula II (II). Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.

Claims (8)

1. A compound having the structure:

wherein R2, R3, R4 and R5 are independently F or H, wherein at least one of R2, R3, R4 and R5 is F and

R is H or CH 3 .

2. The compound of claim 1 , wherein R2 is F.

3. The compound of claim 1 , having the formula:

4. The compound of claim 1 , having the formula

5. A pharmaceutical composition comprising the compound of claim 1 in a pharmaceutically acceptable excipient.

6. The compound of claim 1 , which is an (R) isomer.

Assignments (1)
CHANGE OF NAME Recorded Aug 20, 2019
From: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
To: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Reel/Frame 050102/0485 →