System and method for minimally invasive disease therapy

1. A system for treating a lesion, comprising:

an introducer cannula defining a lumen therein;

a stylet configured to be removably inserted into the cannula lumen;

a resecting device configured to remove the lesion after being removably inserted into the cannula lumen, thereby creating a cavity within tissue adjacent the lesion;

an adjuvant treatment device configured to be removably inserted into the respective cannula lumen and tissue cavity, the adjuvant treatment device configured to deliver an adjuvant treatment to the tissue adjacent the lesion; and

a vacuum source fluidly connected to the cannula lumen so as to deliver vacuum to the tissue cavity while the adjuvant treatment device is disposed within the cannula lumen and tissue cavity, such that the tissue defining the tissue cavity collapses onto a distal end portion of the adjuvant treatment device disposed within the tissue cavity.

2. The system of claim 1 , wherein the adjuvant treatment device is a brachytherapy device.

3. The system of claim 2 , wherein the brachytherapy device comprises

a tubular body defining a first tubular body lumen,

an expandable body attached to the tubular body, and

a radiation source configured to be removably inserted through the first tubular body lumen and into the expandable body.

4. The system of claim 3 , wherein the tubular body further defines a second tubular body lumen and an inflation port inside of the expandable body, wherein the inflation port is fluidly connected to the second tubular body lumen.

5. The system of claim 1 , wherein, when the adjuvant treatment device is inserted into the cannula lumen, the introducer cannula and the adjuvant treatment device together define an annular lumen fluidly connecting the vacuum source to the tissue cavity.