Rapidly disintegrating coated tablets
View Patent ↗Coated dosage forms comprising a tablet core, preferably in compressed form, that has a coating over its exterior surface and one or more patterns debossed in the tablet surface are disclosed. Methods for manufacturing such dosage forms are also disclosed.
1. A dosage form comprising:
a) a core having an exterior surface and first and second ends;
b) at least one debossed pattern in said core;
wherein said at least one debossed pattern contains at least one wall;
wherein the at least one wall contains a wall angle from vertical of about 25 degrees or less; and
c) a coating over portions of the exterior surface of the core.
2. The dosage form of claim 1 , wherein the at least one debossed pattern contains a depth of more than about 0.25 mm.
3. The dosage form of claim 1 , wherein the coating is a film-based coating.
4. The dosage form of claim 3 , wherein the film-based coating comprises hydroxypropylmethylcellulose.
5. The dosage form of claim 1 , comprising at least two debossed patterns in said core.
6. The dosage form of claim 1 , wherein the core is a compressed tablet.
7. The dosage form of claim 6 , wherein the compressed tablet has an elongated shape.
8. The dosage form of claim 1 , wherein the core comprises at least one active ingredient and wherein the dosage form allows for dissolution of the at least one active ingredient following an immediate release profile.
9. The dosage form of claim 8 , wherein the at least one active ingredient is selected from the group consisting of acetaminophen, acetyl salicylic acid, ibuprofen, naproxen, ketoprofen, flurbiprofen, diclofenac, cyclobenzaprine, pseudoephedrine, phenylephrine, phenylpropanolamine, chlorpheniramine, dextromethorphan, diphenhydramine, astemizole, terfenadine, fexofenadine, loratadine, desloratadine, cetirizine, and pharmaceutically acceptable salts, esters, and isomers thereof.
10. The dosage form of claim 1 , wherein the coating is less than or equal to about 5% by weight as compared to a weight of the dosage form.
11. The dosage form of claim 9 , wherein coating weight gain is less than or equal to about 3%.
12. A method for producing a dosage form comprising:
a) debossing at least one pattern on a core, wherein said at least one debossed pattern contains at least one wall, and wherein the at least one wall contains a wall angle from vertical of about 25 degrees or less; and
b) coating said core with a coating material.
13. The method of claim 12 , wherein the dosage form is an elongated tablet.
14. The method of claim 12 , wherein the coating near the at least one debossed pattern disintegrates at a faster rate than the coating on the remaining surface face of the tablet.
15. The method of claim 12 , wherein a thickness of the coating in the at least one pattern is at least 10% lower than a thickness of the coating on a remainder of said tablet.
16. The dosage form of claim 5 , wherein the at least two debossed patterns intersect.