Methods of synthesizing factor Xa inhibitors
View Patent ↗Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof.
1. A composition comprising at least 99.7% betrixaban free base or at least 99.7% betrixaban maleate salt.
2. The composition of claim 1 , comprising at least 99.8% betrixaban maleate salt.
3. The composition of claim 2 , comprising at least 99.9% betrixaban maleate salt.
4. A composition comprising betrixaban free base or salt thereof that comprises less than 0.15% of Compound L and/or Compound M:
5. The composition of claim 4 wherein the salt is the maleate salt.