Microchip
A microchip which includes a fluid circuit defined by a space formed in the microchip and migrates a liquid present in the fluid circuit to a desired position in the fluid circuit by an applied centrifugal force, and a movement path control region (a surface region where an uneven pattern is formed on an inner surface of the fluid circuit) for controlling a movement path of the fluid.
1. A microchip having a fluid circuit defined by a space formed in the microchip and configured to move a liquid present in the fluid circuit from a first position to a second position in the fluid circuit by applying a centrifugal force in a predetermined direction, the microchip comprising:
a first liquid retaining portion including a first opening through which the liquid is discharged, and containing the liquid;
a second opening disposed at a first position towards a first direction, to which the centrifugal force is applied, with respect to the first opening;
a second liquid retaining portion disposed at a second position towards the first direction with respect to the second opening, and including a third opening through which the liquid is received from the first liquid retaining portion;
a protrusion portion, extending from the first opening in a second direction perpendicular to the first direction beyond an edge of the second opening, configured to divert the liquid from the second opening and to prevent back flow of the liquid to the second opening at the time the centrifugal force is applied; and
a flow path connecting the first and second retaining portions past the second opening.
2. The microchip of claim 1 , wherein the protrusion portion is provided on the bottom surface of the fluid circuit.
3. The microchip of claim 1 , wherein the protrusion portion includes a plurality of linear protrusions arranged in parallel at intervals.
4. The microchip of claim 1 , wherein the protrusion portion includes a plurality of protrusions arranged in the first direction.
5. The microchip of claim 1 , wherein the protrusion portion is formed to incline more towards the first direction than the second direction.
6. The microchip of claim 1 , wherein the microchip is formed by sequentially stacking and bonding a first substrate, a second substrate having grooves on both surfaces of the second substrate, and a third substrate,
wherein the fluid circuit comprises:
a first fluid circuit formed by a surface of the first substrate facing the second substrate and the grooves on a surface of the second substrate facing the first substrate; and
a second fluid circuit formed by a surface of the third substrate facing the second substrate and the grooves on a surface of the second substrate facing the third substrate.
7. The microchip of claim 6 , wherein the first fluid circuit includes the first and second liquid retaining portion, and
wherein the second opening penetrates through the second substrate and connects the first fluid circuit and second fluid circuit.
8. The microchip of claim 1 , wherein the second and third openings are sequentially arranged on an opposite side from the second direction with respect to the first opening.
9. The microchip of claim 1 , wherein the liquid includes a whole blood sample, and the second liquid retaining portion is configured to separate the liquid into a blood plasma component and a blood cell component.
10. The microchip of claim 2 , wherein the protrusion portion is arranged such that the liquid passes over the protrusion portion.