IP Library › Granted Patent US 8,679,059
Granted Patent B2
US 8,679,059 · App. 13/764,314 · Granted Mar 25, 2014

Immobilizing objects in the body

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Quick Facts
Patent No.
US 8,679,059
App. No.
13/764,314
Granted
Mar 25, 2014
Kind
B2
Abstract

Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

Claims (24)

1. A system for introducing a material that becomes a gel at or above about body temperature into a cavity or space within a patient's body comprising:

a flowable material which remains in a liquid form below about a temperature inside the body of the patient and which forms a gel about at and above the temperature inside the body of a patient; and

a device for transferring the material into the patient's body in flowable form, whereby the flowable material is transferred in a liquid form from the device into a cavity or space within the patient's body.

2. The system of claim 1 , wherein the flowable material comprises a block copolymer with reverse thermal gelation properties.

3. The system of claim 1 , wherein the flowable material comprises a polyoxyethylene-polyoxypropylene block copolymer.

4. The system of claim 1 , wherein the flowable material comprises a polyoxyethylene-polyoxypropylene block copolymer, wherein the molecular weight of the block copolymer is between 5,000 and 25,000 or between 7,000 and 15,000.

5. The system of claim 1 , wherein the flowable material comprises a biodegradable polyoxyethylene-polyoxypropylene block copolymer.

6. The system of claim 1 , wherein the flowable material comprises copolymers of polyethylene oxide and polypropylene oxide.

7. The system of claim 1 , wherein the flowable material comprises pluronic acid.

8. The system of claim 1 , wherein the flowable material comprises pluronic acid in a solution of phosphate buffered saline.

9. The system of claim 1 , wherein the flowable material comprises pluronic acid and further comprises a dye, hormone, therapeutic agent, filler, or an antibiotic.

10. The system of claim 1 , wherein the flowable material has a temperature below ambient air temperature prior to transfer into the cavity or space within the patient's body.

11. The system of claim 1 , wherein the device is a percutaneous access device.

12. The system of claim 1 , wherein the device is a percutaneous access device having a needle.

13. The system of claim 1 , wherein the device is a catheter.

14. The system of claim 1 , wherein the device is an injection device that applies pressure to the flowable material to force it in a liquid form from the injection device.

15. The system of claim 1 , wherein the flowable material forms a seal or plug in the cavity or space within the patient's body.

16. The system of claim 1 , wherein the flowable material is a carrier for chemical compounds, drugs, hormones, dyes, or other additives that enhance the effectiveness, safety or functionality of the gel.

17. The system of claim 1 , wherein the flowable material comprises a lower critical solution temperature material.

18. The system of claim 1 , wherein the device comprises an automated or human-operated syringe.

19. The system of claim 1 , wherein the device comprises an automated or human-operated syringe comprising a needle.

20. A system for introducing a material that becomes a gel at or above about body temperature into a cavity or space within a patient's body comprising:

a flowable material comprising a polyoxyethylene-polyoxypropylene block copolymer, which remains in a liquid form below about a temperature inside the body of the patient and which forms a gel about at and above the temperature inside the body of a patient; and

an automated or human-operated syringe comprising a needle for transferring the material into the patient's body in flowable form, whereby the flowable material is transferred in a liquid form from the needle into a cavity or space within the patient's body, and wherein the flowable material forms a seal or plug in the cavity or space within the patient's body.