Linear polyesteramides from aminophenolic esters

1. A synthetic polymer comprising monomer units represented by the formula:

wherein R is —(CR 3 R 4 ) a — or —CR 3 ═CR 4 —;

R 1 is hydrogen; saturated or unsaturated alkyl, aryl, alkylaryl or alkyl ether having from 1 to 20 carbon atoms; or —(R 5 ) q O((CR 3 R 4 ) r O) s —R 6 ;

each R 2 is independently a divalent, linear or branched, substituted or unsubstituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, divalent alkyl ether or aryl ether moiety having from 1 to 30 carbon atoms; —(R 5 ) q O((CR 3 R 4 ) r O) s (R 5 ) q —; or —(R 5 ) q CO 2 ((CR 3 R 4 ) r O) s CO(R 5 ) q —;

R 3 and R 4 are each independently, hydrogen or linear or branched, substituted or unsubstituted alkyl having from 1 to 10 carbon atoms,

R 5 is independently linear or branched lower alkylene or lower alkenylene;

R 6 is independently linear or branched, substituted or unsubstituted, saturated or unsaturated lower alkyl;

the aromatic ring has from zero to four Z 1 substituents, each of which is independently selected from the group consisting of halide, lower alkyl, alkoxy, nitro, alkyl ether, a protected hydroxyl group, a protected amino group and a protected carboxylic acid group;

Y is

a is 0, or 2 to 10;

each q is independently 1 to 4; each r is independently 1 to 4; and

each s is independently 1 to 5000.

2. A synthetic polymer comprising monomer units represented by the formula:

wherein R is —(CR 3 R 4 ) a — or —CR3═CR4-;

R 1 is hydrogen; saturated or unsaturated alkyl, aryl, alkylaryl or alkyl ether having from 1 to 20 carbon atoms; or —(R 5 ) q O((CR 3 R 4 ) r O) s —R 6 ;

each R 2 is independently a divalent, linear or branched, substituted or unsubstituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, divalent alkyl ether or aryl ether moiety having from 1 to 30 carbon atoms; —(R 5 ) q O((CR 3 R 4 ) r O) s (R 5 ) q —; or —(R 5 ) q CO 2 ((CR 3 R 4 ) r O) s CO(R 5 ) q —;

R 3 and R 4 are each independently, hydrogen or linear or branched, substituted or unsubstituted alkyl having from 1 to 10 carbon atoms,

R 5 is independently linear or branched lower alkylene or lower alkenylene;

R 6 is independently linear or branched, substituted or unsubstituted, saturated or unsaturated lower alkyl;

the aromatic ring has from zero to four Z 1 substituents, each of which is independently selected from the group consisting of halide, lower alkyl, alkoxy, nitro, alkyl ether, a protected hydroxyl group, a protected amino group and a protected carboxylic acid group;

Y is

a is 0 to 10;

each q is independently 1 to 4; each r is independently 1 to 4; and

each s is independently 1 to 5000.

3. A pharmaceutical composition comprising the polymer of claim 2 and one or more drugs.

4. The pharmaceutical composition of claim 3 , wherein said one or more drugs are selected from the group consisting of antimicrobial agents, antibacterial agents, anesthetics, anti-inflammatory agents, anti-scarring agents, anti-fibrotic agents, leukotriene inhibitors, chemotherapeutic agents.

5. The pharmaceutical composition of claim 4 , wherein said one or more drugs is an antimicrobial agent selected from the group consisting of rifampin, minocycline, gentamicin, vancomycin, triclosan, and combinations thereof.

6. A synthetic polymer comprising monomer units represented by the formula:

wherein R is —(CR 3 R 4 ) a — or —CR 3 ═CR 4 —;

R 1 is hydrogen; saturated or unsaturated alkyl, aryl, alkylaryl or alkyl ether having from 1 to 20 carbon atoms; or —(R 5 ) q O((CR 3 R 4 ) r O) s —R 6 ;

each R 2 is independently a divalent, linear or branched, substituted or unsubstituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, divalent alkyl ether or aryl ether moiety having from 1 to 30 carbon atoms; —(R 5 ) q O((CR 3 R 4 ) r O) s (R 5 ) q —; or —(R 5 ) q CO 2 ((CR 3 R 4 ) r O) s CO(R 5 ) q —;

R 3 and R 4 are each independently, hydrogen or linear or branched, substituted or unsubstituted alkyl having from 1 to 10 carbon atoms,

R 5 is independently linear or branched lower alkylene or lower alkenylene;

R 6 is independently linear or branched, substituted or unsubstituted, saturated or unsaturated lower alkyl;

the aromatic ring has from zero to four Z 1 substituents, each of which is independently selected from the group consisting of halide, lower alkyl, alkoxy, nitro, alkyl ether, a protected hydroxyl group, a protected amino group and a protected carboxylic acid group;

Y is

a is 0 to 10;

each q is independently 1 to 4; each r is independently 1 to 4; and

each s is independently 1 to 5000.

7. The polymer of claim 6 , wherein each R 1 is independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, butyl and benzyl.

8. The polymer of claim 7 , wherein R is methylene or ethylene.

9. The polymer of claim 6 , wherein each R 2 is independently selected from the group consisting of methyl, ethyl, n-propyl, —CH 2 OCH 2 —, and —(CH 2 ) q CO 2 —(CH 2 CH 2 —O) s —C(O)—(CH 2 ) q —, and —(CH 2 ) q O(CH 2 CH 2 O) s (CH 2 ) q —.

10. A pharmaceutical composition comprising the polymer of any one of claim 6 , and one or more drugs.

11. The pharmaceutical composition claim 10 , wherein said one or more drugs are selected from the group consisting of antimicrobial agents, antibacterial agents, anesthetics, anti-inflammatory agents, anti-scarring agents, anti-fibrotic agents, leukotriene inhibitors, chemotherapeutic agents.

12. The composition of claim 11 , wherein said one or more drugs is an antimicrobial agent selected from the group consisting of rifampin, minocycline, gentamicin, vancomycin, triclosan, and combinations thereof.

13. The composition of claim 10 , wherein said one or more drugs is selected from the group consisting of rifampin, minocycline, anesthetics, and anti-inflammatory agents.