Silver containing wound dressing
View Patent ↗A wound dressing having anti-microbial activity comprises a first fiber capable of bonding with silver (1) cations. The wound dressing comprises a blend of the first fiber to which silver (1) cations are bonded and a second fiber which is substantially free from silver. The wound dressing comprises from 0.01 to 5.0 percent by weight of silver (1) cations, based on the weight of fiber.
1. A light-stable wound dressing comprising gel-forming fibers having anti-microbial activity, comprising a first fibre which is gel-forming and substantially insoluble in water having silver (I) cations bonded by ion-exchange thereto and discoloring on exposure to light, the addition of silver having no significant effect on the absorbency of the first fibre, wherein the wound dressing consists of a uniform blend of the first fibre and a second fibre of lyocell which is substantially free from silver, said wound dressing comprising from 0.01 to 5.0 percent by weight of silver (I) cations based on the total weight of first and second fibres, whereby the discoloration of the blend on exposure to light is lessened compared with the discoloration on exposure to light of a batch of the first fibre having the same average amount of silver cations present as is present in the blend.
2. A wound dressing according to claim 1 , which comprises from 0.01 to 4.0 percent by weight of silver (I) cations based on the total weight of first and second fibres.
3. A wound dressing according to claim 1 , which comprises from 0.25 to 3.0 percent by weight of silver (I) cations based on the total weight of first and second fibres.
4. A wound dressing according to claim 1 , wherein the first fibre is selected from a group consisting of a carboxymethylcellulose fibre, an alginate fibre, a chitosan fibre and a chitosan derivative fibre.
5. A wound dressing according to claim 4 , wherein the first fibre is a carboxymethylcellulose fibre and the wound dressing contains from 1.0 to 2.0 percent by weight of silver (I) cations, based on the weight of the fibre.
6. A wound dressing according to claim 4 , wherein the first fibre is an alginate fibre and the wound dressing contains from 0.25 to 0.75 percent by weight of silver (I) cations, based on the weight of the fibre.
7. A wound dressing according to claim 1 , wherein the second fibre contains no silver or low levels of silver such that it does not discolor at all.
8. A wound dressing according to claim 1 , wherein the ratio of the first fibre to the second fibre is in the range of from 5 to 20% by weight of the total weight of the fibre.
9. A wound dressing according to claim 1 , wherein the ratio of the first fibre to the second fibre is in the range of from 0.5 to 25% by weight of the total weight of the fibre.
10. A wound dressing according to claim 1 , wherein the first fibre includes at least 8% by weight, based on the weight of the fibre, of silver (I) cations.
11. A wound dressing according to claim 10 , wherein the first fibre is prepared using at least a 4% silver nitrate solution.
12. A wound dressing according to claim 1 , wherein the first fibre having silver (I) cations bonded thereto is pre-exposed to light prior to blending with the second fiber.
13. A wound dressing according to claim 1 , wherein the first fibre is a carboxymethylcellulose fibre and the degree of substitution of the carboxymethylcellulose fibre is less than 0.4.