High mass throughput particle generation using multiple nozzle spraying
Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.
1. An apparatus for electrospraying particles, the apparatus comprising:
a particle source;
a dispensing device configured to receive source material from the particle source, wherein the dispensing device comprises a slit defined by at least two opposing surfaces terminating at a dispensing end of the dispensing device, wherein the dispensing device defines a plurality of nozzle structures spaced along the slit at the dispensing end of the dispensing device, wherein each nozzle structure comprises at least one nozzle projection extending a distance beyond portions of the at least two opposing surfaces terminating along the slit defined at the dispensing end of the dispensing device to provide a cone jet to spray microdroplets; and
an electrode isolated from the dispensing end, wherein a nonuniform electrical field is created between the dispensing end and the electrode such that a spray of microdroplets having an electrical charge applied thereto is dispensed from the dispensing end of dispensing device.
2. The apparatus of claim 1 , wherein the electrode is a grounded target.
3. The apparatus of claim 1 , wherein each of the nozzle structures comprises a portion of the defined slit without a post therein.
4. The apparatus of claim 1 , wherein each of the nozzle structures comprises a tapered portion at the dispensing end, and further wherein at least a part of each of the nozzle structures extends from an integral multiple nozzle structure portion.
5. The apparatus of claim 1 , wherein each of the nozzle structures comprises a post member provided in a portion of the defined slit.
6. The apparatus of claim 1 , wherein each nozzle projection of the nozzle structures are positioned in an x-y plane orthogonal to a center axis thereof aligned along a z axis of the dispensing device.
7. The apparatus of claim 1 , wherein the plurality of nozzle structures comprises a non-linear configuration of nozzle structures.
8. The apparatus of claim 7 , wherein the plurality of nozzle structures comprises a circular configuration of nozzle structures.
9. The apparatus of claim 1 , wherein the particles have a nominal diameter of about 1 nanometers to about 2000 nanometers.
10. The apparatus of claim 1 , wherein each of the nozzle structures comprise at least a first and second opening terminating at the dispensing.
11. The apparatus of claim 1 , wherein the particle source comprises a particle source that provides at least a first fluid composition using compression of the source material.
12. The apparatus of claim 1 , wherein the slit for receiving source material comprises at least one linear slit.
13. The apparatus of claim 12 , wherein the plurality of nozzle structures are aligned in an array.
14. The apparatus of claim 1 , wherein the plurality of nozzle structures are spaced along a slit defined between first and second opposing surfaces terminating at a dispensing end of the dispensing device, wherein each nozzle structure comprises at least one nozzle projection extending from at least one of first and second opposing surfaces a distance beyond other portions of the first and second opposing surfaces at the dispensing end of the dispensing device to provide a cone jet to spray microdroplets.