Compositions and Methods for the Therapy and Diagnosis of Influenza
The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
1 . An isolated fully human monoclonal anti-matrix 2 ectodomain (M2e) antibody comprising:
a) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 44 and a light chain sequence comprising amino acid sequence SEQ ID NO: 46;
b) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 319 and a light chain sequence comprising amino acid sequence SEQ ID NO: 46;
c) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 321 and a light chain sequence comprising amino acid sequence SEQ ID NO: 46;
d) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 50 and a light chain sequence comprising amino acid sequence SEQ ID NO: 52;
e) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 323 and a light chain sequence comprising amino acid sequence SEQ ID NO: 52; or
f) a heavy chain sequence comprising the amino acid sequence of SEQ ID NO: 325 and a light chain sequence comprising amino acid sequence SEQ ID NO: 52.