Nucleoside phosphoramidates
A nucleoside compound having activity against hepatitis C virus is disclosed.
1. A compound represented by formula I, or a stereoisomer, salt, or pharmaceutically acceptable salt thereof:
wherein
Z is
R 5 is hydrogen; R 6 is CH 3 ; X is F; R 8 is OCH 3 , —N(—CH 2 CH 2 CH 2 —), O-benzyl, or OH; and R 9 is NH 2 .
2. A pharmaceutical composition comprising a pharmaceutically acceptable medium and a compound according to claim 1 .
3. A method of treating a subject infected with a virus selected from the group consisting of hepatitis C virus, West Nile virus, yellow fever virus, dengue virus, rhinovirus, polio virus, hepatitis A virus, bovine viral diarrhea virus and Japanese encephalitis virus which comprises administering to the subject a therapeutically effective amount of a compound according to claim 1 .
4. The method of to claim 3 wherein the subject is infected with hepatitis C virus.
5. A method of treating a subject in need thereof, which comprises contacting at least one hepatitis C virus infected cell with at least one compound according to claim 1 .
6. A compound represented by formula I, or a stereoisomer thereof:
wherein
Z is
R 5 is hydrogen; R 6 is CH 3 ; X is F; R 8 is OCH 3 , —N(—CH 2 CH 2 CH 2 —), O-benzyl, or OH; and R 9 is NH 2 .
7. A pharmaceutical composition comprising a pharmaceutically acceptable medium and a compound according to claim 6 .
8. A method of treating a subject infected with a virus selected from the group consisting of hepatitis C virus, West Nile virus, yellow fever virus, dengue virus, rhinovirus, polio virus, hepatitis A virus, bovine viral diarrhea virus and Japanese encephalitis virus which comprises administering to the subject a therapeutically effective amount of a compound according to claim 6 .
9. The method of to claim 8 wherein the subject is infected with hepatitis C virus.
10. A method of treating a subject in need thereof, which comprises contacting at least one hepatitis C virus infected cell with at least one compound according to claim 6 .
11. The compound of claim 1 wherein R 8 is OCH 3 .
12. The compound of claim 1 wherein R 8 is OH.
13. A pharmaceutical composition comprising a pharmaceutically acceptable medium and a compound according to claim 11 .
14. A pharmaceutical composition comprising a pharmaceutically acceptable medium and a compound according to claim 12 .
15. A method of treating a subject infected with a virus selected from the group consisting of hepatitis C virus, West Nile virus, yellow fever virus, dengue virus, rhinovirus, polio virus, hepatitis A virus, bovine viral diarrhea virus and Japanese encephalitis virus which comprises administering to the subject a therapeutically effective amount of a compound according to claim 11 .
16. The method of claim 15 wherein the subject is infected with hepatitis C virus.
17. A method of treating a subject in need thereof, which comprises contacting at least one hepatitis C virus infected cell with at least one compound according to claim 11 .
18. A method of treating a subject infected with a virus selected from the group consisting of hepatitis C virus, West Nile virus, yellow fever virus, dengue virus, rhinovirus, polio virus, hepatitis A virus, bovine viral diarrhea virus and Japanese encephalitis virus which comprises administering to the subject a therapeutically effective amount of a compound according to claim 12 .
19. The method of claim 18 wherein the subject is infected with hepatitis C virus.
20. A method of treating a subject in need thereof, which comprises contacting at least one hepatitis C virus infected cell with at least one compound according to claim 12 .