IP Library › Granted Patent US 9,115,065
Granted Patent B2
US 9,115,065 · App. 13/777,630 · Granted Aug 25, 2015

Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with Arenaviruses

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Quick Facts
Patent No.
US 9,115,065
App. No.
13/777,630
Granted
Aug 25, 2015
Kind
B2
Abstract

Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

Claims (21)

1. A compound selected from the group consisting of: 1-[1,1-bis(trifluoromethyl)propyl]-3-[(2,4,6-trimethylphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(4-tert-butylphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(2,5-dimethoxyphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-(2-naphthylsulfonylamino)urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(4-isopropylphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(5-chloro-2-methoxy-phenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(2-phenylphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(3,4-dichlorophenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(4-bromophenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[[4-(difluoromethoxy)phenyl]sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(3,5-dimethylphenyl)sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[[5-(dimethylamino)-1-naphthyl]sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-(1-naphthylsulfonylamino)urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl)sulfonylamino]urea;

1-[[2,5-bis(2,2,2-trifluoroethoxy)phenyl]sulfonylamino]-3-[1,1-bis(trifluoromethyl)propyl]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[[4-(thiadiazol-4-yl)phenyl]sulfonylamino]urea;

1-[1,1-bis(trifluoromethyl)propyl]-3-[(5-bromo-2-methoxy-phenyl)sulfonylamino]urea; and

1-[1,1-bis(trifluoromethyl)propyl]-3-[(4-phenylphenyl)sulfonylamino]urea.

2. The compound of claim 1 , wherein the compound is

1-[1,1-bis(trifluoromethyl)propyl]-3-[[4-(thiadiazol-4-yl)phenyl]sulfonylamino]urea.

3. The compound of claim 1 , wherein the compound is 1-[1,1-bis(trifluoromethyl)propyl]-3-[[5-(dimethylamino)-1-naphthyl]sulfonylamino]urea.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 22, 2014
From: SIGA TECHNOLOGIES INC.
To: KINETA FOUR LLC
Reel/Frame 033588/0427 →