Catheter lock solution comprising citrate and a paraben
View Patent ↗This invention relates to compositions, methods, devices and kits relating to the infusion of a catheter lock solution into an indwelling catheter. Inventive compositions, methods, devices and kits aid in diminishing the effects of microbial infection in catheters and occlusion of the catheters. A lock solution provided by the invention includes citrate and a paraben. The solution preferably has a density suitable for retention of the solution in a catheter during the lock period. Another lock solution provided by the invention includes citrate, a paraben and a photo-oxidant, such as, for example, methylene blue.
1. An aqueous antimicrobial composition comprising about 1.5 to about 47% citrate and about 0.005 to about 0.6% (g/100 ml) or the solubility limit of a paraben dispersed or dissolved therein.
2. The aqueous antimicrobial composition of claim 1 , wherein the paraben is methyl paraben, propyl paraben, or a combination thereof.
3. The aqueous antimicrobial composition of claim 1 , wherein the composition comprises about 0.005 to about 0.5 percent (g/100 ml) methyl paraben.
4. The aqueous antimicrobial composition of claim 1 , wherein the composition comprises about 0.005 to about 0.5 percent (g/100 ml) propyl paraben.
5. The aqueous antimicrobial composition of claim 1 , wherein the composition comprises about 0.05 to about 0.5 percent (g/100 ml) methyl paraben, and about 0.005 to about 0.5 percent (g/100 ml) propyl paraben.
6. The aqueous antimicrobial composition of claim 1 , wherein the concentration of citrate in the solution is at least as high as the calcium concentration in a patient's blood.
7. The aqueous antimicrobial composition of claim 1 , wherein the citrate has a concentration of from about 1.5 to about 15% by weight.
8. The aqueous antimicrobial composition of claim 1 , wherein the citrate is trisodium citrate dihydrate.
9. The aqueous antimicrobial composition of claim 1 , wherein the pH of the solution is from about 4 to about 8.
10. The aqueous antimicrobial composition of claim 1 , wherein the relative density of the solution is from about 1.000 to about 1.300 g/ml.
11. The aqueous antimicrobial composition of claim 1 , wherein the solution further comprises a viscosifying agent.
12. The aqueous antimicrobial composition of claim 1 , further comprising alcohol.
13. The aqueous antimicrobial composition of claim 1 , wherein the paraben has a concentration of about 0.1 percent to about 0.3 percent.
14. The aqueous antimicrobial composition of claim 1 comprising about 0.01-1 M citrate.
15. The aqueous antimicrobial composition of claim 14 , wherein the paraben has a concentration of about 0.1% to about 0.3% by weight.
16. A method of locking a catheter comprising introducing an aqueous antimicrobial composition of claim 1 into a lumen of the catheter.
17. The aqueous antimicrobial composition of claim 1 , wherein the paraben has a concentration of from about 0.005 to about 0.6% percent (g/100 ml).
18. The aqueous antimicrobial composition of claim 14 , wherein the paraben has a concentration of from about 0.005 to about 0.6% percent (g/100 ml).