Method and system for treatment of cardiovascular disorders
View Patent ↗Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
1. A method of treating ischemic heart disease of a subject, the ischemic heart disease presenting with ischemic infarcted cardiovascular tissue, the method comprising the steps of:
providing an extracellular matrix (ECM) composition comprising acellular small intestine submucosa (SIS), said ECM composition further comprising 0.1 μM of cerivastatin wherein the cerivastatin is mixed with the ECM composition;
providing a mechanical circulatory support (MSC) device that is configured to support ventricular function of a mammalian heart when connected thereto;
connecting said MSC device to said subject's circulatory system;
administering said ECM composition proximate said ischemic infarcted cardiovascular tissue of said subject's heart, wherein said ECM composition inhibits localized expression of proinflammatory chemokine monocyte chemoattractant protein-1 (MCP-1) and proinflammatory receptor C—C chemokine receptor type-2 (CCR2),
whereby inflammation of said infarcted cardiovascular tissue is reduced and bioremodeling and regeneration of new cardiovascular tissue is induced; and
providing support of ventricular function of said subject's heart with said MSC device, wherein said heart exhibits a post-treatment ejection fraction, said post-treatment ejection fraction being greater relative to said heart's ejection fraction by providing said MSC or administration of said ECM composition alone.
2. The method of claim 1 , wherein said ECM composition is administered directly to said ischemic infarcted cardiovascular tissue.
3. The method of claim 1 , wherein said MSC device comprises a left ventricular assist device (LVAD).
4. The method of claim 1 , wherein said MSC device comprises a right ventricular assist device (RVAD).