IP Library › Granted Patent US 8,986,709
Granted Patent B2
US 8,986,709 · App. 13/782,754 · Granted Mar 24, 2015

Vaccine for prophylaxis or treatment of an allergen-driven airway pathology

Inventors: Camille Locht (Lille Cedex, FR); Bernard Mahon (Maynooth, IE); Heather Kavanagh (Maynooth, IE)
Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale); Institut Pasteur de Lille; National University of Ireland Maynooth
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Quick Facts
Patent No.
US 8,986,709
App. No.
13/782,754
Granted
Mar 24, 2015
Kind
B2
Abstract

The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.

Claims (4)

1. A method for reducing airway inflammation in a subject which develops airway inflammation in response to exposure to an allergen, the method comprising the step of infecting the subject with a live Bordetella pertussis strain which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT), wherein the step of infecting the subject results in reduction of airway inflammation in said subject.

2. The method of claim 1 , wherein the subject has been diagnosed with asthma.

3. The method of claim 1 , wherein the subject has been diagnosed with interstitial lung disease.

4. The method of claim 1 , wherein the subject has been diagnosed with hay fever.

Assignments (2)
SECURITY INTEREST Recorded Sep 23, 2024
From: ILIAD BIOTECHNOLOGIES, LLC
To: AVENUE CAPITAL MANAGEMENT II, L.P.
Reel/Frame 068668/0854 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2013
From: LOCHT, CAMILLE; MAHON, BERNARD; KAVANAGH, HEATHER
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); INSTITUT PASTEUR DE LILLE; NATIONAL UNIVERSITY OF IRELAND MAYNOOTH
Reel/Frame 030692/0556 →
Priority Claims (1)
EP 09305371 · Apr 28, 2009 · regional
Continuity (2)
Division 13266561
Related Publication 20130183336A1 · Jul 18, 2013