Penetrating pharmaceutical foam
View Patent ↗The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.
1. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;
ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;
iii) about 0.01% to about 5% by weight of the carrier of a gelling agent; and
iv) water,
wherein the surface active agent is selected from the group consisting of polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myrj 52 (polyoxyethylene 40 stearate);
wherein a breakable foam forms upon dispensing the foamable composition.
2. The foamable composition of claim 1 , wherein the carrier further comprises a therapeutically effective amount of at least one active agent.
3. The foamable composition of claim 1 , wherein the liquefied or compressed gas propellant is at a concentration of about 3% to about 18% by weight of the carrier.
4. The foamable composition of claim 1 , wherein the carrier is an oil in water emulsion.
5. The foamable composition of claim 1 , wherein the carrier further comprises about 1% to about 30% by weight of the carrier of a therapeutic enhancer.
6. The foamable composition of claim 5 , wherein the therapeutic enhancer is selected from the group consisting of a polyhydric alcohol, propylene glycol, butylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, an oligosaccharide, dimethyl isosorbide, monooleate of ethoxylated glycerides (with 8 to 10 ethylene oxide units), a polyethylene glycol 200-600, transcutol (diethylene glycol monoethyl ether), glycofurol (tetrahydrofurfuryl alcohol PEG ether), a cyclodextrin, and mixtures of any two or more thereof.
7. The foamable composition of claim 1 , wherein the breakable foam has a specific gravity of between about 0.01 g/mL and about 0.1 g/mL.
8. The foamable composition of claim 1 , wherein the carrier further comprises a foam adjuvant.
9. The foamable composition of claim 1 , wherein the hydrophobic solvent is selected from the group consisting of vegetable oil, marine oil, mineral oil, an emollient, silicone oil, a plant-derived therapeutic oil, and mixtures of any two or more thereof.
10. The foamable composition of claim 2 , wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.
11. The foamable composition of claim 1 , wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:8 and about 1:16.
12. The foamable composition of claim 1 , wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:16 and about 1:32.
13. The foamable composition of claim 1 , wherein the carrier contains no more than 7.5% by weight of the carrier of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof.
14. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;
ii) 0.01% to about 5% by weight of the carrier of a gelling agent;
iii) a therapeutic enhancer selected from the group consisting of a polyhydric alcohol, propylene glycol, butylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, an oligosaccharide, dimethyl isosorbide, monooleate of ethoxylated glycerides (with 8 to 10 ethylene oxide units), a polyethylene glycol 200-600, transcutol (diethylene glycol monoethyl ether), glycofurol (tetrahydrofurfuryl alcohol PEG ether), a cyclodextrin, and mixtures of any two or more thereof; and
iv) water,
wherein a breakable foam forms upon dispensing the foamable composition.
15. The foamable composition of claim 14 , wherein the liquefied or compressed gas propellant is at a concentration of about 3% to about 18% by weight of the carrier.
16. The foamable composition of claim 14 , wherein the carrier further comprises a therapeutically effective amount of at least one active agent.
17. The foamable composition of claim 14 , wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.
18. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;
ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;
iii) about 0.01% to about 5% by weight of the carrier of a gelling agent;
iv) a foam adjuvant; and
iv) water,
wherein a breakable foam forms upon dispensing the foamable composition.
19. The foamable composition of claim 18 , wherein the surface-active agent is selected from the group consisting of a non ionic surface-active agent, a cationic surface-active agent, an amphoteric surface-active agent, a zwitterionic-surface active agent, and mixtures of any two or more thereof.
20. A foamable composition comprising a carrier and a liquefied or a compressed gas propellant, the carrier comprising:
i) about 0.1% to about 5% by weight of the carrier of a surface-active agent;
ii) about 2% to about 75% by weight of the carrier of a liquid, non-volatile hydrophobic solvent;
iii) about 0.01% to about 5% by weight of the carrier of a gelling agent; and
iv) water,
wherein the ratio of surface active agent to hydrophobic solvent is about 1:8 to about 1:16; and
wherein a breakable foam forms upon dispensing the foamable composition.
21. The foamable composition of claim 18 , wherein the surface-active agent is a non-ionic surfactant.
22. The foamble composition of claim 18 , wherein the carrier further comprises a therapeutically effective amount of at least one active agent.
23. The foamble composition of claim 22 , wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.
24. The foamable composition of claim 20 , wherein the surface-active agent is a mixture of a non ionic surface-active agent and an ionic surface-active agent in a 1:1 to 20:1 ratio.
25. The foamble composition of claim 20 , wherein the hydrophobic solvent is about 20% to about 50% by weight of the carrier.
26. The foamble composition of claim 20 , wherein the hydrophobic solvent is 10% to about 20% by weight of the carrier.
27. The foamble composition of claim 20 , wherein the carrier further comprises a therapeutically effective amount of at least one active agent.
28. The foamble composition of claim 27 , wherein the active agent is selected from the group consisting of an antibacterial agent, an anti-fungal agent, an anti-viral agent, an anti-inflammatory agent, a steroid, a corticosteroid, anti-histamine, a nonsteroidal anti-inflammatory agent, an immunomodulating agent, an immunosuppressant, an anti-allergic agent, a local anesthetic agent, a keratolytically active agent, a retinoid, an insecticide, an insect repellent, an anti-cancer drug, a photodynamic therapy agent, an active agent for burns, wounds, cuts and ulcers, an anti-acne active agent, an anti-wrinkle active agent, an anti-atrophy active agent, an anti-oxidant, a radical scavenger, a self-tanning active agent, a skin lightening or whitening agent, an agent suitable for the treatment of a hair growth disorder, a humectant, a moisture-retaining agent, a hydroxy acid, an agent for treating cellulite, and mixtures of any two or more thereof.